The effect of indomethacin on blood pressure in a rat model of preeclampsia

I. Buhimsch, George Saade, K. Chwalisz, R. Garfield

Research output: Contribution to journalArticle

Abstract

OBJECTFVE: To determine if inhibition of the cyclooxygenase enzyme affects the hypertension induced by nitric oxide synihase blockade in a previously characterized rat model of preeclampsia. STUDY DESIGN: As previously reported, a preeclampsia-like condition was induced by infusing pregnant rats with the nitric oxide synthase inhibitor, L-NAME. Timed, pregnant Harlan-Sprague-Dawley rats (average weight 220 g) were given either vehicle (control group), L-NAME 50 mg/d (L-NAME group), indomethadn 0.1 rng/d (INDO group) or combination (L-NAME + INDO group) starting on day 17 of pregnancy (term 22 days). Vehicle and L-NAME were delivered continuously using subcutaneously implanted osmotic minipumps. Indomethacin was given in two daily subcutaneous injections. Blood pressure was measured with the tailcuff method before any treatments and daily until postpartum day 2. Data presented as mean ±SE. RESULTS: Except for an increase on the day following insertion of the pump, indomethacin had no significant effect on the hypertension induced by L-NAME. CONCLUSIONS: Non-selective inhibition of all the products of the cyclooxygenase enzyme does not influence the hypertension described with the preeclampsia-like condition induced by nitric oxide deficiency in the rat. Our findings do not exclude a role for relative deficiency or excess of individual cyclooxygenase enzyme products.

Original languageEnglish (US)
JournalActa Diabetologica Latina
Volume176
Issue number1 PART II
StatePublished - 1997
Externally publishedYes

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NG-Nitroarginine Methyl Ester
Pre-Eclampsia
Indomethacin
Blood Pressure
Prostaglandin-Endoperoxide Synthases
Hypertension
Nitric Oxide
Enzymes
Subcutaneous Injections
Nitric Oxide Synthase
Postpartum Period
Sprague Dawley Rats
Weights and Measures
Pregnancy
Control Groups

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

The effect of indomethacin on blood pressure in a rat model of preeclampsia. / Buhimsch, I.; Saade, George; Chwalisz, K.; Garfield, R.

In: Acta Diabetologica Latina, Vol. 176, No. 1 PART II, 1997.

Research output: Contribution to journalArticle

Buhimsch, I, Saade, G, Chwalisz, K & Garfield, R 1997, 'The effect of indomethacin on blood pressure in a rat model of preeclampsia', Acta Diabetologica Latina, vol. 176, no. 1 PART II.
Buhimsch, I. ; Saade, George ; Chwalisz, K. ; Garfield, R. / The effect of indomethacin on blood pressure in a rat model of preeclampsia. In: Acta Diabetologica Latina. 1997 ; Vol. 176, No. 1 PART II.
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