The effect of insulin-like growth factor I on postburn hypermetabolism

L. L. Strock, Harbans Singh, A. Abdullah, J. A. Miller, David Herndon

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

These studies were undertaken to examine the effects of insulin-like growth factor I (IGF-I) on the hypermetabolic state that follows major thermal injury. Male Sprague-Dawley rats weighing 275 to 325 gm were subjected to a 50% total body surface area, full-thickness scald burn. At the time of injury, osmotic pumps were surgically implanted and used to deliver IGF-I, 1000 μg/day, or an equivalent volume of placebo solution by constant infusion of 5 μl/hr for 14 days. Metabolic rates were studied with oxygen-consumption measurements performed on days 3, 7, 10, and 14 after injury. Animal weight measurements were also performed at the above intervals, with serum total IGF-I levels measured at death. Total serum IGF-I levels were decreased significantly 14 days after injury compared with uninjured animals (p < 0.05). Treatment with IGF-I resulted in a significant decrease in oxygen consumption and a significant increase in body weight compared with burned animals and those treated with placebo 10 and 14 days after injury (p < 0.05). These data suggest that IGF-I causes a significant change in the metabolic response that follows severe thermal injury and point to a possible role for IGF-I in the treatment of patients after severe thermal injury.

Original languageEnglish (US)
Pages (from-to)161-164
Number of pages4
JournalSurgery
Volume108
Issue number2
StatePublished - 1990

Fingerprint

Insulin-Like Growth Factor I
Wounds and Injuries
Hot Temperature
Oxygen Consumption
Placebos
Body Surface Area
Serum
Sprague Dawley Rats
Body Weight
Weights and Measures
Therapeutics

ASJC Scopus subject areas

  • Surgery

Cite this

Strock, L. L., Singh, H., Abdullah, A., Miller, J. A., & Herndon, D. (1990). The effect of insulin-like growth factor I on postburn hypermetabolism. Surgery, 108(2), 161-164.

The effect of insulin-like growth factor I on postburn hypermetabolism. / Strock, L. L.; Singh, Harbans; Abdullah, A.; Miller, J. A.; Herndon, David.

In: Surgery, Vol. 108, No. 2, 1990, p. 161-164.

Research output: Contribution to journalArticle

Strock, LL, Singh, H, Abdullah, A, Miller, JA & Herndon, D 1990, 'The effect of insulin-like growth factor I on postburn hypermetabolism', Surgery, vol. 108, no. 2, pp. 161-164.
Strock LL, Singh H, Abdullah A, Miller JA, Herndon D. The effect of insulin-like growth factor I on postburn hypermetabolism. Surgery. 1990;108(2):161-164.
Strock, L. L. ; Singh, Harbans ; Abdullah, A. ; Miller, J. A. ; Herndon, David. / The effect of insulin-like growth factor I on postburn hypermetabolism. In: Surgery. 1990 ; Vol. 108, No. 2. pp. 161-164.
@article{fd480bbab3c5414c8d3bcbae978bbe75,
title = "The effect of insulin-like growth factor I on postburn hypermetabolism",
abstract = "These studies were undertaken to examine the effects of insulin-like growth factor I (IGF-I) on the hypermetabolic state that follows major thermal injury. Male Sprague-Dawley rats weighing 275 to 325 gm were subjected to a 50{\%} total body surface area, full-thickness scald burn. At the time of injury, osmotic pumps were surgically implanted and used to deliver IGF-I, 1000 μg/day, or an equivalent volume of placebo solution by constant infusion of 5 μl/hr for 14 days. Metabolic rates were studied with oxygen-consumption measurements performed on days 3, 7, 10, and 14 after injury. Animal weight measurements were also performed at the above intervals, with serum total IGF-I levels measured at death. Total serum IGF-I levels were decreased significantly 14 days after injury compared with uninjured animals (p < 0.05). Treatment with IGF-I resulted in a significant decrease in oxygen consumption and a significant increase in body weight compared with burned animals and those treated with placebo 10 and 14 days after injury (p < 0.05). These data suggest that IGF-I causes a significant change in the metabolic response that follows severe thermal injury and point to a possible role for IGF-I in the treatment of patients after severe thermal injury.",
author = "Strock, {L. L.} and Harbans Singh and A. Abdullah and Miller, {J. A.} and David Herndon",
year = "1990",
language = "English (US)",
volume = "108",
pages = "161--164",
journal = "Surgery",
issn = "0039-6060",
publisher = "Mosby Inc.",
number = "2",

}

TY - JOUR

T1 - The effect of insulin-like growth factor I on postburn hypermetabolism

AU - Strock, L. L.

AU - Singh, Harbans

AU - Abdullah, A.

AU - Miller, J. A.

AU - Herndon, David

PY - 1990

Y1 - 1990

N2 - These studies were undertaken to examine the effects of insulin-like growth factor I (IGF-I) on the hypermetabolic state that follows major thermal injury. Male Sprague-Dawley rats weighing 275 to 325 gm were subjected to a 50% total body surface area, full-thickness scald burn. At the time of injury, osmotic pumps were surgically implanted and used to deliver IGF-I, 1000 μg/day, or an equivalent volume of placebo solution by constant infusion of 5 μl/hr for 14 days. Metabolic rates were studied with oxygen-consumption measurements performed on days 3, 7, 10, and 14 after injury. Animal weight measurements were also performed at the above intervals, with serum total IGF-I levels measured at death. Total serum IGF-I levels were decreased significantly 14 days after injury compared with uninjured animals (p < 0.05). Treatment with IGF-I resulted in a significant decrease in oxygen consumption and a significant increase in body weight compared with burned animals and those treated with placebo 10 and 14 days after injury (p < 0.05). These data suggest that IGF-I causes a significant change in the metabolic response that follows severe thermal injury and point to a possible role for IGF-I in the treatment of patients after severe thermal injury.

AB - These studies were undertaken to examine the effects of insulin-like growth factor I (IGF-I) on the hypermetabolic state that follows major thermal injury. Male Sprague-Dawley rats weighing 275 to 325 gm were subjected to a 50% total body surface area, full-thickness scald burn. At the time of injury, osmotic pumps were surgically implanted and used to deliver IGF-I, 1000 μg/day, or an equivalent volume of placebo solution by constant infusion of 5 μl/hr for 14 days. Metabolic rates were studied with oxygen-consumption measurements performed on days 3, 7, 10, and 14 after injury. Animal weight measurements were also performed at the above intervals, with serum total IGF-I levels measured at death. Total serum IGF-I levels were decreased significantly 14 days after injury compared with uninjured animals (p < 0.05). Treatment with IGF-I resulted in a significant decrease in oxygen consumption and a significant increase in body weight compared with burned animals and those treated with placebo 10 and 14 days after injury (p < 0.05). These data suggest that IGF-I causes a significant change in the metabolic response that follows severe thermal injury and point to a possible role for IGF-I in the treatment of patients after severe thermal injury.

UR - http://www.scopus.com/inward/record.url?scp=0025046009&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025046009&partnerID=8YFLogxK

M3 - Article

VL - 108

SP - 161

EP - 164

JO - Surgery

JF - Surgery

SN - 0039-6060

IS - 2

ER -