The effect of interobserver variation in dating endometrial histology on the diagnosis of luteal phase defects

R. T. Scott, R. R. Snyder, D. M. Strickland, C. C. Tyburski, J. A. Bagnall, K. R. Reed, C. A. Adair, S. B. Hensley

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Endometrial biopsy specimens (n = 62) were evaluated by five pathologists to assess the effect of interobserver variation on histologic dating of the endometrium. The potential effect of this variation on the diagnosis of luteal phase defects (LPDs) and resulting clinical management was also determined. Mean (± standard error) interobserver variation was 0.96 ± 0.08 days, comparable to results reported by other investigators. The magnitude of the variation was not affected by whether the biopsy specimen was obtained in the mid or late luteal phase, the degree of lag between the dating and subsequent menses, or the presence of an LPD. Redating of a specimen by another pathologist would have resulted in a change in the determination of 'in' or 'out' of phase in 22% of cases. The subsequent probability of changing patient management altered ranged from 22% to 39% depending on the clinical setting.

Original languageEnglish (US)
Pages (from-to)888-892
Number of pages5
JournalFertility and Sterility
Volume50
Issue number6
DOIs
StatePublished - Jan 1 1988
Externally publishedYes

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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    Scott, R. T., Snyder, R. R., Strickland, D. M., Tyburski, C. C., Bagnall, J. A., Reed, K. R., Adair, C. A., & Hensley, S. B. (1988). The effect of interobserver variation in dating endometrial histology on the diagnosis of luteal phase defects. Fertility and Sterility, 50(6), 888-892. https://doi.org/10.1016/S0015-0282(16)60367-9