The effect of lipid peroxides on isolated human umbilical artery contraction

George R. Saade, Michael A. Belfort, David Johnson, Yuri P. Vedernikov, Helen Hughes, Maya Suresh, Kenneth J. Moise

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

OBJECTIVE: Our purpose was to determine the effect of oxidized lipids on the contractile activity of isolated human umbilical arteries. STUDY DESIGN: Umbilical artery rings were prepared for isometric tension recording and exposed to cumulative concentrations of oxidized and nonoxidized lipid and control solutions. Rings were also incubated with the lipid or control solutions and then contracted with cumulative concentrations of U46619. A final set of rings in Ca++-free depolarized solution was incubated with the agents above, and then the Ca++ concentration was increased cumulatively. RESULTS: The lipids had no direct contractile effect. Both lipids inhibited the response to U46619 and Ca++, with the oxidized lipids having the most significant effect. CONCLUSION: Oxidized lipids lack a direct contractile effect on isolated human umbilical arteries and inhibit the contractile response to thromboxane and calcium.

Original languageEnglish (US)
Pages (from-to)825-830
Number of pages6
JournalAmerican journal of obstetrics and gynecology
Volume172
Issue number3
DOIs
StatePublished - Mar 1995
Externally publishedYes

Keywords

  • Human
  • contraction
  • in vitro
  • lipid peroxide
  • umbilical artery

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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    Saade, G. R., Belfort, M. A., Johnson, D., Vedernikov, Y. P., Hughes, H., Suresh, M., & Moise, K. J. (1995). The effect of lipid peroxides on isolated human umbilical artery contraction. American journal of obstetrics and gynecology, 172(3), 825-830. https://doi.org/10.1016/0002-9378(95)90006-3