Abstract
OBJECTIVES: Our purpose was to determine the effect of a 6 gm intravenous bolus of magnesium sulfate on maternal retinal blood flow velocity waveforms in patients with preeclampsia. STUDY DESIGN: Twenty-two patients were randomized to two groups and were studied with color flow Doppler before and immediately after infusion of either 6 gm of magnesium sulfate or placebo. The central retinal and posterior ciliary arteries were studied. RESULTS: Magnesium sulfate significantly reduced the pulsatility index (p < 0.005) in both vessels (change in pulsatility index = -0.26 ± 0.23 for central retinal and -0.22 ± 0.15 for posterior ciliary) when compared with placebo (change in pulsatility index = 0.02 ± 0.10 for central retinal and -0.03 ± 0.09 for posterior ciliary). CONCLUSIONS: These data suggest that magnesium sulfate dilates the vessels distal to the central retinal and posterior ciliary arteries. Changes in pulsatility index in the retinal arteries may be indicative of similar changes in other cerebral vessels.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1548-1553 |
| Number of pages | 6 |
| Journal | American Journal of Obstetrics and Gynecology |
| Volume | 167 |
| Issue number | 6 |
| DOIs | |
| State | Published - 1992 |
| Externally published | Yes |
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Keywords
- Magnesium sulfate
- preeclampsia
- retinal blood flow
ASJC Scopus subject areas
- Medicine(all)
- Obstetrics and Gynecology
Cite this
The effect of magnesium sulfate on maternal retinal blood flow in preeclampsia : A randomized placebo-controlled study. / Belfort, Michael A.; Saade, George; Moise, Kenneth J.
In: American Journal of Obstetrics and Gynecology, Vol. 167, No. 6, 1992, p. 1548-1553.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effect of magnesium sulfate on maternal retinal blood flow in preeclampsia
T2 - A randomized placebo-controlled study
AU - Belfort, Michael A.
AU - Saade, George
AU - Moise, Kenneth J.
PY - 1992
Y1 - 1992
N2 - OBJECTIVES: Our purpose was to determine the effect of a 6 gm intravenous bolus of magnesium sulfate on maternal retinal blood flow velocity waveforms in patients with preeclampsia. STUDY DESIGN: Twenty-two patients were randomized to two groups and were studied with color flow Doppler before and immediately after infusion of either 6 gm of magnesium sulfate or placebo. The central retinal and posterior ciliary arteries were studied. RESULTS: Magnesium sulfate significantly reduced the pulsatility index (p < 0.005) in both vessels (change in pulsatility index = -0.26 ± 0.23 for central retinal and -0.22 ± 0.15 for posterior ciliary) when compared with placebo (change in pulsatility index = 0.02 ± 0.10 for central retinal and -0.03 ± 0.09 for posterior ciliary). CONCLUSIONS: These data suggest that magnesium sulfate dilates the vessels distal to the central retinal and posterior ciliary arteries. Changes in pulsatility index in the retinal arteries may be indicative of similar changes in other cerebral vessels.
AB - OBJECTIVES: Our purpose was to determine the effect of a 6 gm intravenous bolus of magnesium sulfate on maternal retinal blood flow velocity waveforms in patients with preeclampsia. STUDY DESIGN: Twenty-two patients were randomized to two groups and were studied with color flow Doppler before and immediately after infusion of either 6 gm of magnesium sulfate or placebo. The central retinal and posterior ciliary arteries were studied. RESULTS: Magnesium sulfate significantly reduced the pulsatility index (p < 0.005) in both vessels (change in pulsatility index = -0.26 ± 0.23 for central retinal and -0.22 ± 0.15 for posterior ciliary) when compared with placebo (change in pulsatility index = 0.02 ± 0.10 for central retinal and -0.03 ± 0.09 for posterior ciliary). CONCLUSIONS: These data suggest that magnesium sulfate dilates the vessels distal to the central retinal and posterior ciliary arteries. Changes in pulsatility index in the retinal arteries may be indicative of similar changes in other cerebral vessels.
KW - Magnesium sulfate
KW - preeclampsia
KW - retinal blood flow
UR - http://www.scopus.com/inward/record.url?scp=0026621467&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026621467&partnerID=8YFLogxK
U2 - 10.1016/0002-9378(92)91737-U
DO - 10.1016/0002-9378(92)91737-U
M3 - Article
C2 - 1471663
AN - SCOPUS:0026621467
VL - 167
SP - 1548
EP - 1553
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 6
ER -