The effect of nerve growth factor and antibodies to nerve growth factor on ethylnitrosourea carcinogenesis in mice

Stanley A. Vinores, J. Regino Perez-Polo

    Research output: Contribution to journalArticlepeer-review

    6 Scopus citations

    Abstract

    The specific induction of neural tumors by the carcinogen, ethylnitrosourea (ENU), can be enhanced by reducing the in vivo nerve growth factor (NGF) levels in mice using IgG directed against the biologically active subunit of NGF (anti-NGF). This effect is reversible, confirming that the altered endogenous NGF levels do return to normal following injection with anit-NGF. Correspondingly, no neural tumors were observed when in vivo NGF levels were elevated by administering exogenous NGF with ENU. The higher physiological levels of NGF in control mice when compared to control rats might explain why fetal administration of ENU to rats results in a greater percentage of neural tumors. This would suggest that the long studied maturation effect that NGF has on developing neural cells of the peripheral nervous system may also influence neural oncogenesis.

    Original languageEnglish (US)
    Pages (from-to)59-63
    Number of pages5
    JournalJournal of Cancer Research and Clinical Oncology
    Volume98
    Issue number1
    DOIs
    StatePublished - Oct 1 1980

    Keywords

    • Chemical carcinogenesis
    • Ethylnitrosourea
    • Nerve growth factor
    • Neural oncogenesis

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

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