The effect of oxytocin on uterine contractility and electromyographic activity recorded from the rat abdominal

Surface C. Bukimschi, I. Buhimschi, George Saade, K. Chwalisz, R. Garfield

Research output: Contribution to journalArticle

Abstract

OBJECTIVES: To determine if the electromyographic (EMG) recording of uterine activity obtained from the abdominal surface can be used as a non-invasive measure of uterine contractility and if the electrical power density spectrum (PDS) correlates with the efficiency of oxytocin stimulation in the rat. STUDY DESIGN: EMG activity was acquired by use of unipolar electrodes attached simultaneously to the uterine wall (UT) and abdominal surface (AS). EMG activity was recorded in the 0.3 - 50 Hz range and digitized at 200 samples/s. Intrauterine pressure (IUP) was measured continuously using a catheter implanted in the uterus. The effect of additive doses of oxytocin on PDS and integrated IUP was recorded in the anesthetized rats at term. RESULTS: Bursts of EMG activity recorded from AS mirrored those from the UT, albeit at a lower amplitude. At lower oxytocin concentrations, PDS energy and IUP increased and contractions were phasic with return to the baseline in between. As oxytocin concentration increased, the energy declined while the IUP continued to rise (figure). This increase was due to the onset of tetanic contractions and a progressive increase in the baseline tone. CONCLUSIONS: Uterine electrical activity can be reliably recorded from the abdominal surface and may be a useful, non-invasive, method to study myometrial function and pharmacology in-vivo. Analysis of the uterine electrical energy may be a better indicator of the efficiency of myometrial contraction than pressure or traditional tocodynamometry alone. Additional studies to evaluate this technology in humans are warranted.

Original languageEnglish (US)
JournalActa Diabetologica Latina
Volume176
Issue number1 PART II
StatePublished - 1997
Externally publishedYes

Fingerprint

Oxytocin
Pressure
Uterine Monitoring
Uterine Contraction
Abdominal Wall
Uterus
Electrodes
Catheters
Pharmacology
Technology

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

The effect of oxytocin on uterine contractility and electromyographic activity recorded from the rat abdominal. / Bukimschi, Surface C.; Buhimschi, I.; Saade, George; Chwalisz, K.; Garfield, R.

In: Acta Diabetologica Latina, Vol. 176, No. 1 PART II, 1997.

Research output: Contribution to journalArticle

Bukimschi, Surface C. ; Buhimschi, I. ; Saade, George ; Chwalisz, K. ; Garfield, R. / The effect of oxytocin on uterine contractility and electromyographic activity recorded from the rat abdominal. In: Acta Diabetologica Latina. 1997 ; Vol. 176, No. 1 PART II.
@article{60f34ec30d1d4a41a29be19e446e5e5f,
title = "The effect of oxytocin on uterine contractility and electromyographic activity recorded from the rat abdominal",
abstract = "OBJECTIVES: To determine if the electromyographic (EMG) recording of uterine activity obtained from the abdominal surface can be used as a non-invasive measure of uterine contractility and if the electrical power density spectrum (PDS) correlates with the efficiency of oxytocin stimulation in the rat. STUDY DESIGN: EMG activity was acquired by use of unipolar electrodes attached simultaneously to the uterine wall (UT) and abdominal surface (AS). EMG activity was recorded in the 0.3 - 50 Hz range and digitized at 200 samples/s. Intrauterine pressure (IUP) was measured continuously using a catheter implanted in the uterus. The effect of additive doses of oxytocin on PDS and integrated IUP was recorded in the anesthetized rats at term. RESULTS: Bursts of EMG activity recorded from AS mirrored those from the UT, albeit at a lower amplitude. At lower oxytocin concentrations, PDS energy and IUP increased and contractions were phasic with return to the baseline in between. As oxytocin concentration increased, the energy declined while the IUP continued to rise (figure). This increase was due to the onset of tetanic contractions and a progressive increase in the baseline tone. CONCLUSIONS: Uterine electrical activity can be reliably recorded from the abdominal surface and may be a useful, non-invasive, method to study myometrial function and pharmacology in-vivo. Analysis of the uterine electrical energy may be a better indicator of the efficiency of myometrial contraction than pressure or traditional tocodynamometry alone. Additional studies to evaluate this technology in humans are warranted.",
author = "Bukimschi, {Surface C.} and I. Buhimschi and George Saade and K. Chwalisz and R. Garfield",
year = "1997",
language = "English (US)",
volume = "176",
journal = "Acta Diabetologica",
issn = "0940-5429",
publisher = "Springer-Verlag Italia",
number = "1 PART II",

}

TY - JOUR

T1 - The effect of oxytocin on uterine contractility and electromyographic activity recorded from the rat abdominal

AU - Bukimschi, Surface C.

AU - Buhimschi, I.

AU - Saade, George

AU - Chwalisz, K.

AU - Garfield, R.

PY - 1997

Y1 - 1997

N2 - OBJECTIVES: To determine if the electromyographic (EMG) recording of uterine activity obtained from the abdominal surface can be used as a non-invasive measure of uterine contractility and if the electrical power density spectrum (PDS) correlates with the efficiency of oxytocin stimulation in the rat. STUDY DESIGN: EMG activity was acquired by use of unipolar electrodes attached simultaneously to the uterine wall (UT) and abdominal surface (AS). EMG activity was recorded in the 0.3 - 50 Hz range and digitized at 200 samples/s. Intrauterine pressure (IUP) was measured continuously using a catheter implanted in the uterus. The effect of additive doses of oxytocin on PDS and integrated IUP was recorded in the anesthetized rats at term. RESULTS: Bursts of EMG activity recorded from AS mirrored those from the UT, albeit at a lower amplitude. At lower oxytocin concentrations, PDS energy and IUP increased and contractions were phasic with return to the baseline in between. As oxytocin concentration increased, the energy declined while the IUP continued to rise (figure). This increase was due to the onset of tetanic contractions and a progressive increase in the baseline tone. CONCLUSIONS: Uterine electrical activity can be reliably recorded from the abdominal surface and may be a useful, non-invasive, method to study myometrial function and pharmacology in-vivo. Analysis of the uterine electrical energy may be a better indicator of the efficiency of myometrial contraction than pressure or traditional tocodynamometry alone. Additional studies to evaluate this technology in humans are warranted.

AB - OBJECTIVES: To determine if the electromyographic (EMG) recording of uterine activity obtained from the abdominal surface can be used as a non-invasive measure of uterine contractility and if the electrical power density spectrum (PDS) correlates with the efficiency of oxytocin stimulation in the rat. STUDY DESIGN: EMG activity was acquired by use of unipolar electrodes attached simultaneously to the uterine wall (UT) and abdominal surface (AS). EMG activity was recorded in the 0.3 - 50 Hz range and digitized at 200 samples/s. Intrauterine pressure (IUP) was measured continuously using a catheter implanted in the uterus. The effect of additive doses of oxytocin on PDS and integrated IUP was recorded in the anesthetized rats at term. RESULTS: Bursts of EMG activity recorded from AS mirrored those from the UT, albeit at a lower amplitude. At lower oxytocin concentrations, PDS energy and IUP increased and contractions were phasic with return to the baseline in between. As oxytocin concentration increased, the energy declined while the IUP continued to rise (figure). This increase was due to the onset of tetanic contractions and a progressive increase in the baseline tone. CONCLUSIONS: Uterine electrical activity can be reliably recorded from the abdominal surface and may be a useful, non-invasive, method to study myometrial function and pharmacology in-vivo. Analysis of the uterine electrical energy may be a better indicator of the efficiency of myometrial contraction than pressure or traditional tocodynamometry alone. Additional studies to evaluate this technology in humans are warranted.

UR - http://www.scopus.com/inward/record.url?scp=33748625972&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748625972&partnerID=8YFLogxK

M3 - Article

VL - 176

JO - Acta Diabetologica

JF - Acta Diabetologica

SN - 0940-5429

IS - 1 PART II

ER -