The effect of propranolol on catecholamine clearance

Michael G. Ziegler, Bart Chernow, Lee C. Woodson, Joseph Coyle, David Cruess, C. Raymond Lake

    Research output: Contribution to journalArticle

    17 Scopus citations

    Abstract

    Normal subjects given propranolol increased their plasma t 1 2 for infused isoproterenol from 2.68 to 6.25 minutes. Propranolol increased plasma norepinephrine (NE) levels only slightly. Propranolol increased the t 1 2 of isoproterenol but not that of NE in men with autonomic nervous system degeneration. This suggests that propranolol acts on nonneuronal uptake-2 processes, rather than on uptake-1 mechanisms. α-Blockers slow uptake-1 and β-blockers slow uptake-2 processes. When 27 subjects exercised, those who attained the highest plasma levels of the α- and β-receptor agonist NE also had the briefest apparent t 1 2 for NE. Adrenergic receptor blocking drugs slow catecholamine clearance. NE may stimulate its own clearance.

    Original languageEnglish (US)
    Pages (from-to)116-119
    Number of pages4
    JournalClinical Pharmacology and Therapeutics
    Volume40
    Issue number1
    DOIs
    StatePublished - Jul 1986

    ASJC Scopus subject areas

    • Pharmacology
    • Pharmacology (medical)

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  • Cite this

    Ziegler, M. G., Chernow, B., Woodson, L. C., Coyle, J., Cruess, D., & Lake, C. R. (1986). The effect of propranolol on catecholamine clearance. Clinical Pharmacology and Therapeutics, 40(1), 116-119. https://doi.org/10.1038/clpt.1986.147