Abstract
Normal subjects given propranolol increased their plasma t 1 2 for infused isoproterenol from 2.68 to 6.25 minutes. Propranolol increased plasma norepinephrine (NE) levels only slightly. Propranolol increased the t 1 2 of isoproterenol but not that of NE in men with autonomic nervous system degeneration. This suggests that propranolol acts on nonneuronal uptake-2 processes, rather than on uptake-1 mechanisms. α-Blockers slow uptake-1 and β-blockers slow uptake-2 processes. When 27 subjects exercised, those who attained the highest plasma levels of the α- and β-receptor agonist NE also had the briefest apparent t 1 2 for NE. Adrenergic receptor blocking drugs slow catecholamine clearance. NE may stimulate its own clearance.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 116-119 |
| Number of pages | 4 |
| Journal | Clinical Pharmacology and Therapeutics |
| Volume | 40 |
| Issue number | 1 |
| State | Published - Jul 1986 |
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ASJC Scopus subject areas
- Pharmacology
Cite this
The effect of propranolol on catecholamine clearance. / Ziegler, Michael G.; Chernow, Bart; Woodson, Lee C.; Coyle, Joseph; Cruess, David; Lake, C. Raymond.
In: Clinical Pharmacology and Therapeutics, Vol. 40, No. 1, 07.1986, p. 116-119.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effect of propranolol on catecholamine clearance
AU - Ziegler, Michael G.
AU - Chernow, Bart
AU - Woodson, Lee C.
AU - Coyle, Joseph
AU - Cruess, David
AU - Lake, C. Raymond
PY - 1986/7
Y1 - 1986/7
N2 - Normal subjects given propranolol increased their plasma t 1 2 for infused isoproterenol from 2.68 to 6.25 minutes. Propranolol increased plasma norepinephrine (NE) levels only slightly. Propranolol increased the t 1 2 of isoproterenol but not that of NE in men with autonomic nervous system degeneration. This suggests that propranolol acts on nonneuronal uptake-2 processes, rather than on uptake-1 mechanisms. α-Blockers slow uptake-1 and β-blockers slow uptake-2 processes. When 27 subjects exercised, those who attained the highest plasma levels of the α- and β-receptor agonist NE also had the briefest apparent t 1 2 for NE. Adrenergic receptor blocking drugs slow catecholamine clearance. NE may stimulate its own clearance.
AB - Normal subjects given propranolol increased their plasma t 1 2 for infused isoproterenol from 2.68 to 6.25 minutes. Propranolol increased plasma norepinephrine (NE) levels only slightly. Propranolol increased the t 1 2 of isoproterenol but not that of NE in men with autonomic nervous system degeneration. This suggests that propranolol acts on nonneuronal uptake-2 processes, rather than on uptake-1 mechanisms. α-Blockers slow uptake-1 and β-blockers slow uptake-2 processes. When 27 subjects exercised, those who attained the highest plasma levels of the α- and β-receptor agonist NE also had the briefest apparent t 1 2 for NE. Adrenergic receptor blocking drugs slow catecholamine clearance. NE may stimulate its own clearance.
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UR - http://www.scopus.com/inward/citedby.url?scp=0022529117&partnerID=8YFLogxK
M3 - Article
VL - 40
SP - 116
EP - 119
JO - Clinical Pharmacology and Therapeutics
JF - Clinical Pharmacology and Therapeutics
SN - 0009-9236
IS - 1
ER -