The effect of propranolol on catecholamine clearance

Michael G. Ziegler, Bart Chernow, Lee C. Woodson, Joseph Coyle, David Cruess, C. Raymond Lake

    Research output: Contribution to journalArticle

    17 Citations (Scopus)

    Abstract

    Normal subjects given propranolol increased their plasma t 1 2 for infused isoproterenol from 2.68 to 6.25 minutes. Propranolol increased plasma norepinephrine (NE) levels only slightly. Propranolol increased the t 1 2 of isoproterenol but not that of NE in men with autonomic nervous system degeneration. This suggests that propranolol acts on nonneuronal uptake-2 processes, rather than on uptake-1 mechanisms. α-Blockers slow uptake-1 and β-blockers slow uptake-2 processes. When 27 subjects exercised, those who attained the highest plasma levels of the α- and β-receptor agonist NE also had the briefest apparent t 1 2 for NE. Adrenergic receptor blocking drugs slow catecholamine clearance. NE may stimulate its own clearance.

    Original languageEnglish (US)
    Pages (from-to)116-119
    Number of pages4
    JournalClinical Pharmacology and Therapeutics
    Volume40
    Issue number1
    StatePublished - Jul 1986

    Fingerprint

    Propranolol
    Catecholamines
    Norepinephrine
    Isoproterenol
    Adrenergic Receptors
    Autonomic Nervous System
    Pharmaceutical Preparations

    ASJC Scopus subject areas

    • Pharmacology

    Cite this

    Ziegler, M. G., Chernow, B., Woodson, L. C., Coyle, J., Cruess, D., & Lake, C. R. (1986). The effect of propranolol on catecholamine clearance. Clinical Pharmacology and Therapeutics, 40(1), 116-119.

    The effect of propranolol on catecholamine clearance. / Ziegler, Michael G.; Chernow, Bart; Woodson, Lee C.; Coyle, Joseph; Cruess, David; Lake, C. Raymond.

    In: Clinical Pharmacology and Therapeutics, Vol. 40, No. 1, 07.1986, p. 116-119.

    Research output: Contribution to journalArticle

    Ziegler, MG, Chernow, B, Woodson, LC, Coyle, J, Cruess, D & Lake, CR 1986, 'The effect of propranolol on catecholamine clearance', Clinical Pharmacology and Therapeutics, vol. 40, no. 1, pp. 116-119.
    Ziegler MG, Chernow B, Woodson LC, Coyle J, Cruess D, Lake CR. The effect of propranolol on catecholamine clearance. Clinical Pharmacology and Therapeutics. 1986 Jul;40(1):116-119.
    Ziegler, Michael G. ; Chernow, Bart ; Woodson, Lee C. ; Coyle, Joseph ; Cruess, David ; Lake, C. Raymond. / The effect of propranolol on catecholamine clearance. In: Clinical Pharmacology and Therapeutics. 1986 ; Vol. 40, No. 1. pp. 116-119.
    @article{d48c3e8d5a004ec38aced2451a2e49eb,
    title = "The effect of propranolol on catecholamine clearance",
    abstract = "Normal subjects given propranolol increased their plasma t 1 2 for infused isoproterenol from 2.68 to 6.25 minutes. Propranolol increased plasma norepinephrine (NE) levels only slightly. Propranolol increased the t 1 2 of isoproterenol but not that of NE in men with autonomic nervous system degeneration. This suggests that propranolol acts on nonneuronal uptake-2 processes, rather than on uptake-1 mechanisms. α-Blockers slow uptake-1 and β-blockers slow uptake-2 processes. When 27 subjects exercised, those who attained the highest plasma levels of the α- and β-receptor agonist NE also had the briefest apparent t 1 2 for NE. Adrenergic receptor blocking drugs slow catecholamine clearance. NE may stimulate its own clearance.",
    author = "Ziegler, {Michael G.} and Bart Chernow and Woodson, {Lee C.} and Joseph Coyle and David Cruess and Lake, {C. Raymond}",
    year = "1986",
    month = "7",
    language = "English (US)",
    volume = "40",
    pages = "116--119",
    journal = "Clinical Pharmacology and Therapeutics",
    issn = "0009-9236",
    publisher = "Nature Publishing Group",
    number = "1",

    }

    TY - JOUR

    T1 - The effect of propranolol on catecholamine clearance

    AU - Ziegler, Michael G.

    AU - Chernow, Bart

    AU - Woodson, Lee C.

    AU - Coyle, Joseph

    AU - Cruess, David

    AU - Lake, C. Raymond

    PY - 1986/7

    Y1 - 1986/7

    N2 - Normal subjects given propranolol increased their plasma t 1 2 for infused isoproterenol from 2.68 to 6.25 minutes. Propranolol increased plasma norepinephrine (NE) levels only slightly. Propranolol increased the t 1 2 of isoproterenol but not that of NE in men with autonomic nervous system degeneration. This suggests that propranolol acts on nonneuronal uptake-2 processes, rather than on uptake-1 mechanisms. α-Blockers slow uptake-1 and β-blockers slow uptake-2 processes. When 27 subjects exercised, those who attained the highest plasma levels of the α- and β-receptor agonist NE also had the briefest apparent t 1 2 for NE. Adrenergic receptor blocking drugs slow catecholamine clearance. NE may stimulate its own clearance.

    AB - Normal subjects given propranolol increased their plasma t 1 2 for infused isoproterenol from 2.68 to 6.25 minutes. Propranolol increased plasma norepinephrine (NE) levels only slightly. Propranolol increased the t 1 2 of isoproterenol but not that of NE in men with autonomic nervous system degeneration. This suggests that propranolol acts on nonneuronal uptake-2 processes, rather than on uptake-1 mechanisms. α-Blockers slow uptake-1 and β-blockers slow uptake-2 processes. When 27 subjects exercised, those who attained the highest plasma levels of the α- and β-receptor agonist NE also had the briefest apparent t 1 2 for NE. Adrenergic receptor blocking drugs slow catecholamine clearance. NE may stimulate its own clearance.

    UR - http://www.scopus.com/inward/record.url?scp=0022529117&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=0022529117&partnerID=8YFLogxK

    M3 - Article

    C2 - 3720174

    AN - SCOPUS:0022529117

    VL - 40

    SP - 116

    EP - 119

    JO - Clinical Pharmacology and Therapeutics

    JF - Clinical Pharmacology and Therapeutics

    SN - 0009-9236

    IS - 1

    ER -