The effect of resuscitation on inhalation injury

David Herndon, D. L. Traber, L. D. Traber

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Eighteen chronically instrumented sheep with lung-lymph catheters were studied. Inhalation injury was produced in 12 animals under halothane anesthesia and then studied for 24 hours. Six of the animals received 70 ml/m2/hr body surface area for 5% dextrose in Ringer's lactated solution (normal maintenance fluid requirements for sheep), and six received 140 ml/m2/hr (twice normal maintenance fluid requirements for sheep). Six additional animals were anesthetized, insufflated with air instead of smoke, and received 70 ml/m2/hr of resuscitation fluid (sham group). Twelve hours after injury, the recorded variables from the animals that were smoked and had received a high fluid resuscitation were not different from the sham group whereas the group with low-volume fluid resuscitation had a much higher lung-lymph flow and lymph-to-plasma protein concentration ratio and a lower cardiac output. The lung microvascular permeability changes seen with smoke inhalation are made worse by inadequate fluid resuscitation.

Original languageEnglish (US)
Pages (from-to)248-251
Number of pages4
JournalSurgery
Volume100
Issue number2
StatePublished - 1986

Fingerprint

Resuscitation
Inhalation
Lymph
Sheep
Wounds and Injuries
Smoke
Lung
Maintenance
Body Surface Area
Capillary Permeability
Halothane
Cardiac Output
Blood Proteins
Catheters
Anesthesia
Air
Glucose

ASJC Scopus subject areas

  • Surgery

Cite this

Herndon, D., Traber, D. L., & Traber, L. D. (1986). The effect of resuscitation on inhalation injury. Surgery, 100(2), 248-251.

The effect of resuscitation on inhalation injury. / Herndon, David; Traber, D. L.; Traber, L. D.

In: Surgery, Vol. 100, No. 2, 1986, p. 248-251.

Research output: Contribution to journalArticle

Herndon, D, Traber, DL & Traber, LD 1986, 'The effect of resuscitation on inhalation injury', Surgery, vol. 100, no. 2, pp. 248-251.
Herndon D, Traber DL, Traber LD. The effect of resuscitation on inhalation injury. Surgery. 1986;100(2):248-251.
Herndon, David ; Traber, D. L. ; Traber, L. D. / The effect of resuscitation on inhalation injury. In: Surgery. 1986 ; Vol. 100, No. 2. pp. 248-251.
@article{f8304c8e9a23406d963a0df0ffd4e19c,
title = "The effect of resuscitation on inhalation injury",
abstract = "Eighteen chronically instrumented sheep with lung-lymph catheters were studied. Inhalation injury was produced in 12 animals under halothane anesthesia and then studied for 24 hours. Six of the animals received 70 ml/m2/hr body surface area for 5{\%} dextrose in Ringer's lactated solution (normal maintenance fluid requirements for sheep), and six received 140 ml/m2/hr (twice normal maintenance fluid requirements for sheep). Six additional animals were anesthetized, insufflated with air instead of smoke, and received 70 ml/m2/hr of resuscitation fluid (sham group). Twelve hours after injury, the recorded variables from the animals that were smoked and had received a high fluid resuscitation were not different from the sham group whereas the group with low-volume fluid resuscitation had a much higher lung-lymph flow and lymph-to-plasma protein concentration ratio and a lower cardiac output. The lung microvascular permeability changes seen with smoke inhalation are made worse by inadequate fluid resuscitation.",
author = "David Herndon and Traber, {D. L.} and Traber, {L. D.}",
year = "1986",
language = "English (US)",
volume = "100",
pages = "248--251",
journal = "Surgery",
issn = "0039-6060",
publisher = "Mosby Inc.",
number = "2",

}

TY - JOUR

T1 - The effect of resuscitation on inhalation injury

AU - Herndon, David

AU - Traber, D. L.

AU - Traber, L. D.

PY - 1986

Y1 - 1986

N2 - Eighteen chronically instrumented sheep with lung-lymph catheters were studied. Inhalation injury was produced in 12 animals under halothane anesthesia and then studied for 24 hours. Six of the animals received 70 ml/m2/hr body surface area for 5% dextrose in Ringer's lactated solution (normal maintenance fluid requirements for sheep), and six received 140 ml/m2/hr (twice normal maintenance fluid requirements for sheep). Six additional animals were anesthetized, insufflated with air instead of smoke, and received 70 ml/m2/hr of resuscitation fluid (sham group). Twelve hours after injury, the recorded variables from the animals that were smoked and had received a high fluid resuscitation were not different from the sham group whereas the group with low-volume fluid resuscitation had a much higher lung-lymph flow and lymph-to-plasma protein concentration ratio and a lower cardiac output. The lung microvascular permeability changes seen with smoke inhalation are made worse by inadequate fluid resuscitation.

AB - Eighteen chronically instrumented sheep with lung-lymph catheters were studied. Inhalation injury was produced in 12 animals under halothane anesthesia and then studied for 24 hours. Six of the animals received 70 ml/m2/hr body surface area for 5% dextrose in Ringer's lactated solution (normal maintenance fluid requirements for sheep), and six received 140 ml/m2/hr (twice normal maintenance fluid requirements for sheep). Six additional animals were anesthetized, insufflated with air instead of smoke, and received 70 ml/m2/hr of resuscitation fluid (sham group). Twelve hours after injury, the recorded variables from the animals that were smoked and had received a high fluid resuscitation were not different from the sham group whereas the group with low-volume fluid resuscitation had a much higher lung-lymph flow and lymph-to-plasma protein concentration ratio and a lower cardiac output. The lung microvascular permeability changes seen with smoke inhalation are made worse by inadequate fluid resuscitation.

UR - http://www.scopus.com/inward/record.url?scp=0022503019&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022503019&partnerID=8YFLogxK

M3 - Article

C2 - 3738753

AN - SCOPUS:0022503019

VL - 100

SP - 248

EP - 251

JO - Surgery

JF - Surgery

SN - 0039-6060

IS - 2

ER -