The effect of self-reported health on latent herpesvirus reactivation and inflammation in an ethnically diverse sample

Kyle W. Murdock, Christopher P. Fagundes, Mary Peek, Vansh Vohra, Raymond P. Stowe

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Self-rated health (SRH) is a reliable predictor of health outcomes including morbidity and mortality. Immune dysregulation is one hypothesized mechanism underlying the association between SRH and health outcomes. Indeed, poorer SRH is associated with greater inflammation. The association between SRH and reactivation of latent herpesviruses is unknown, representing an important gap in the literature given that reactivation of latent herpesviruses leads to enhanced inflammation. The present study addressed this important gap in the literature by examining associations between SRH, inflammation (i.e., peripheral cytokines in the blood), and reactivation of latent herpesviruses among a sample of 1208 individuals participating in the Texas City Stress and Health Study. Participants completed a self-report measure of SRH and a blood draw. Results indicated that higher SRH was associated with lower reactivation of latent herpesviruses and inflammation. Moreover, reactivation of latent herpesviruses partially mediated the association between SRH and inflammation. Accordingly, findings add to our growing understanding of the association between SRH and immune dysfunction.

Original languageEnglish (US)
Pages (from-to)113-118
Number of pages6
JournalPsychoneuroendocrinology
Volume72
DOIs
StatePublished - Oct 1 2016

Keywords

  • Cytomegalovirus
  • Epstein-Barr virus
  • Inflammation
  • Self-rated health

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Endocrine and Autonomic Systems

Fingerprint Dive into the research topics of 'The effect of self-reported health on latent herpesvirus reactivation and inflammation in an ethnically diverse sample'. Together they form a unique fingerprint.

  • Cite this