The effect of sex steroids on radioimmunoassayable plasma somatomedin C concentrations

Walter Meyer, R. W. Furlanetto, P. A. Walker

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

While the effect of sex steroids on growth is well known, their effects on somatomedin C, a mediator of growth, are unclear. To investigate the effect of sex steroids on somatomedin C (Sm-C) concentrations. Sm-C was measured in adults receiving pharmacological doses of various sex steroids (estrogens, testosterone, and medroxyprogesterone acetate). Testosterone therapy had no effect on the somatomedin C concentration. Although both estrogen and medroxyprogesterone acetate therapy reduced the plasma testosterone concentration into the normal female range, they had different effects on Sm-C concentrations. Estrogen therapy produced no detectable change in the Sm-C concentration; medroxyprogesterone acetate caused an increase in the plasma somatomedin C concentration (P <0.001). Since medroxyprogesterone acetate also does not increase the serum GH concentration, other mechanisms by which medroxyprogesterone acetate stimulates Sm-C production are discussed.

Original languageEnglish (US)
Pages (from-to)1184-1187
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume55
Issue number6
StatePublished - 1982

Fingerprint

Insulin-Like Growth Factor I
Medroxyprogesterone Acetate
Steroids
Plasmas
Estrogens
Testosterone
Growth
Reference Values
Therapeutics
Pharmacology
Serum

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

The effect of sex steroids on radioimmunoassayable plasma somatomedin C concentrations. / Meyer, Walter; Furlanetto, R. W.; Walker, P. A.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 55, No. 6, 1982, p. 1184-1187.

Research output: Contribution to journalArticle

Meyer, Walter ; Furlanetto, R. W. ; Walker, P. A. / The effect of sex steroids on radioimmunoassayable plasma somatomedin C concentrations. In: Journal of Clinical Endocrinology and Metabolism. 1982 ; Vol. 55, No. 6. pp. 1184-1187.
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