The effect of sex steroids on radioimmunoassayable plasma somatomedin c concentrations

Walter J. Meyer, Richard W. Furlanetto, W. Furlanetto, Paul A. Walker

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


While the effect of sex steroids on growth is well known, their effects on somatomedin C, a mediator of growth, are unclear. To investigate the effect of sex steroids on somatomedin C (Sm-C) concentrations, Sm-C was measured in adults receiving pharmacological doses of various sex steroids (estrogens, testosterone, and medroxyprogesterone acetate). Testosterone therapy had no effect on the somatomedin C concentration. Although both estrogen and medroxyprogesterone acetate therapy reduced the plasma testosterone concentration into the normal female range, they had different effects on Sm-C concentrations. Estrogen therapy produced no detectable change in the Sm-C concentration; medroxyprogesterone acetate caused an increase in the plasma somatomedin C concentration (P < 0.001). Since medroxyprogesterone acetate also does not increase the serum GH concentration, other mechanisms by which medroxyprogesterone acetate stimulates Sm-C production are discussed.

Original languageEnglish (US)
Pages (from-to)1184-1187
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Issue number6
StatePublished - Dec 1982
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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