The Effect of Sodium Intake on Zinc Excretion in Patients with Sickle Cell Anemia

M. Cassandra Matustik; Arthur B. Chausmer; Walter J. Meyer

doi:10.1080/07315724.1982.10719003

The Effect of Sodium Intake on Zinc Excretion in Patients with Sickle Cell Anemia

M. Cassandra Matustik, Arthur B. Chausmer, Walter J. Meyer

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Urinary zinc excretion is known to be elevated in subjects with sickle cell anemia. Sodium intake has been suggested to influence zinc excretion in normal subjects. In order to assess the effect of sodium on zinc excretion in subjects with sickle cell anemia, urinary zinc excretion was measured in thirteen children and adolescents with sickle cell anemia on both a high (140 mEq/day) and low (20 mEq/day) sodium intake. Urinary zinc excretion was elevated on both diets. The mean urinary zinc excretion on the high sodium diet (775 ± 238 /ig/24h) was significantly lower (P <,005)than that on the low sodium diet (947 ± 344 g/24h). The zinc excretion did not correlate with calcium or magnesium excretion or aldosterone secretion rates or plasma renin activity. Although elevated, the urinary zinc excretion in patients with sickle cell anemia is still significantly lowered by increasing sodium intake.

Original language	English (US)
Pages (from-to)	331-336
Number of pages	6
Journal	Journal of the American College of Nutrition
Volume	1
Issue number	4
DOIs	https://doi.org/10.1080/07315724.1982.10719003
State	Published - Jan 1 1982

Keywords

Sickle cell anemia
Sodium
Zinc

ASJC Scopus subject areas

Medicine (miscellaneous)
Nutrition and Dietetics

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10.1080/07315724.1982.10719003

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title = "The Effect of Sodium Intake on Zinc Excretion in Patients with Sickle Cell Anemia",

abstract = "Urinary zinc excretion is known to be elevated in subjects with sickle cell anemia. Sodium intake has been suggested to influence zinc excretion in normal subjects. In order to assess the effect of sodium on zinc excretion in subjects with sickle cell anemia, urinary zinc excretion was measured in thirteen children and adolescents with sickle cell anemia on both a high (140 mEq/day) and low (20 mEq/day) sodium intake. Urinary zinc excretion was elevated on both diets. The mean urinary zinc excretion on the high sodium diet (775 ± 238 /ig/24h) was significantly lower (P <,005)than that on the low sodium diet (947 ± 344 g/24h). The zinc excretion did not correlate with calcium or magnesium excretion or aldosterone secretion rates or plasma renin activity. Although elevated, the urinary zinc excretion in patients with sickle cell anemia is still significantly lowered by increasing sodium intake.",

keywords = "Sickle cell anemia, Sodium, Zinc",

author = "Matustik, {M. Cassandra} and Chausmer, {Arthur B.} and Meyer, {Walter J.}",

note = "Funding Information: The patients were studied at the Chnical Research Center of the University of Texas Medical Branch supported by grant RR-73 from the General Clinical Research Centers Program of the Division of Research Resources, MIH, PHS. The research was supported by the Department of Pediatrics, University of Texas Medical Branch and Jeanne B. Kempner Fellowship (MCM).",

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AU - Chausmer, Arthur B.

AU - Meyer, Walter J.

N1 - Funding Information: The patients were studied at the Chnical Research Center of the University of Texas Medical Branch supported by grant RR-73 from the General Clinical Research Centers Program of the Division of Research Resources, MIH, PHS. The research was supported by the Department of Pediatrics, University of Texas Medical Branch and Jeanne B. Kempner Fellowship (MCM).

PY - 1982/1/1

Y1 - 1982/1/1

N2 - Urinary zinc excretion is known to be elevated in subjects with sickle cell anemia. Sodium intake has been suggested to influence zinc excretion in normal subjects. In order to assess the effect of sodium on zinc excretion in subjects with sickle cell anemia, urinary zinc excretion was measured in thirteen children and adolescents with sickle cell anemia on both a high (140 mEq/day) and low (20 mEq/day) sodium intake. Urinary zinc excretion was elevated on both diets. The mean urinary zinc excretion on the high sodium diet (775 ± 238 /ig/24h) was significantly lower (P <,005)than that on the low sodium diet (947 ± 344 g/24h). The zinc excretion did not correlate with calcium or magnesium excretion or aldosterone secretion rates or plasma renin activity. Although elevated, the urinary zinc excretion in patients with sickle cell anemia is still significantly lowered by increasing sodium intake.

AB - Urinary zinc excretion is known to be elevated in subjects with sickle cell anemia. Sodium intake has been suggested to influence zinc excretion in normal subjects. In order to assess the effect of sodium on zinc excretion in subjects with sickle cell anemia, urinary zinc excretion was measured in thirteen children and adolescents with sickle cell anemia on both a high (140 mEq/day) and low (20 mEq/day) sodium intake. Urinary zinc excretion was elevated on both diets. The mean urinary zinc excretion on the high sodium diet (775 ± 238 /ig/24h) was significantly lower (P <,005)than that on the low sodium diet (947 ± 344 g/24h). The zinc excretion did not correlate with calcium or magnesium excretion or aldosterone secretion rates or plasma renin activity. Although elevated, the urinary zinc excretion in patients with sickle cell anemia is still significantly lowered by increasing sodium intake.

KW - Sickle cell anemia

KW - Sodium

KW - Zinc

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The Effect of Sodium Intake on Zinc Excretion in Patients with Sickle Cell Anemia

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Keywords

ASJC Scopus subject areas

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