The effect of steatosis on echogenicity of colorectal liver metastases on intraoperative ultrasonography

Mark G. Van Vledder, Michael S. Torbenson, Timothy M. Pawlik, Emad M. Boctor, Ulrike M. Hamper, Kelly Olino, Michael A. Choti

Research output: Contribution to journalArticle

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Abstract

Objective: To investigate the association of relative tumor echogenicity and hepatic steatosis in patients undergoing resection of colorectal liver metastases (CRLM). Design: Prospective study. Setting: The Johns Hopkins Hospital. Patients: A total of 126 patients undergoing liver surgery for CRLM from January 1, 1998, through December 31, 2008, in whom 191 lesions had complete intraoperative ultrasonography images for review and adequate linked pathological data available. Main Outcome Measures: The intraoperative ultrasonography images were reviewed and scored for echogenicity (hypoechoic, isoechoic, or hyperechoic). In addition, a histopathologic review of the nontumorous liver tissue was performed, and the extent of steatosis was scored and correlated with tumor echogenicity. Results: Of the patients undergoing surgery, 49 (38.8%) were found to have mild to severe steatosis. Of the 191 total CRLM visualized by intraoperative ultrasonography, 91 (47.6%) were found to be hypoechoic, 65 (34.0%) were isoechoic, and 35 (18.3%) were hyperechoic. In patients with steatosis, lesions were significantly more likely to be hypoechoic when compared with patients without steatosis (odds ratio, 4.17; 95% confidence interval, 1.87-8.47; P=.001). Echogenicity was independent of the cause of steatosis or response to chemotherapy. Conclusions: The echogenicity of CRLM was significantly affected by the presence of liver steatosis, with decreased echogenicity and increased conspicuity of lesions despite overall poorer image quality. These findings might reinforce the usefulness of intraoperative ultrasonography in identifying additional CRLM in patients undergoing surgical therapy, even in those with fatty liver tissue.

Original languageEnglish (US)
Pages (from-to)661-667
Number of pages7
JournalArchives of Surgery
Volume145
Issue number7
DOIs
StatePublished - Jul 2010
Externally publishedYes

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Ultrasonography
Neoplasm Metastasis
Liver
Fatty Liver
Colorectal Surgery
Adipose Tissue
Neoplasms
Odds Ratio
Outcome Assessment (Health Care)
Prospective Studies
Confidence Intervals
Drug Therapy

ASJC Scopus subject areas

  • Surgery

Cite this

Van Vledder, M. G., Torbenson, M. S., Pawlik, T. M., Boctor, E. M., Hamper, U. M., Olino, K., & Choti, M. A. (2010). The effect of steatosis on echogenicity of colorectal liver metastases on intraoperative ultrasonography. Archives of Surgery, 145(7), 661-667. https://doi.org/10.1001/archsurg.2010.124

The effect of steatosis on echogenicity of colorectal liver metastases on intraoperative ultrasonography. / Van Vledder, Mark G.; Torbenson, Michael S.; Pawlik, Timothy M.; Boctor, Emad M.; Hamper, Ulrike M.; Olino, Kelly; Choti, Michael A.

In: Archives of Surgery, Vol. 145, No. 7, 07.2010, p. 661-667.

Research output: Contribution to journalArticle

Van Vledder, MG, Torbenson, MS, Pawlik, TM, Boctor, EM, Hamper, UM, Olino, K & Choti, MA 2010, 'The effect of steatosis on echogenicity of colorectal liver metastases on intraoperative ultrasonography', Archives of Surgery, vol. 145, no. 7, pp. 661-667. https://doi.org/10.1001/archsurg.2010.124
Van Vledder, Mark G. ; Torbenson, Michael S. ; Pawlik, Timothy M. ; Boctor, Emad M. ; Hamper, Ulrike M. ; Olino, Kelly ; Choti, Michael A. / The effect of steatosis on echogenicity of colorectal liver metastases on intraoperative ultrasonography. In: Archives of Surgery. 2010 ; Vol. 145, No. 7. pp. 661-667.
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abstract = "Objective: To investigate the association of relative tumor echogenicity and hepatic steatosis in patients undergoing resection of colorectal liver metastases (CRLM). Design: Prospective study. Setting: The Johns Hopkins Hospital. Patients: A total of 126 patients undergoing liver surgery for CRLM from January 1, 1998, through December 31, 2008, in whom 191 lesions had complete intraoperative ultrasonography images for review and adequate linked pathological data available. Main Outcome Measures: The intraoperative ultrasonography images were reviewed and scored for echogenicity (hypoechoic, isoechoic, or hyperechoic). In addition, a histopathologic review of the nontumorous liver tissue was performed, and the extent of steatosis was scored and correlated with tumor echogenicity. Results: Of the patients undergoing surgery, 49 (38.8{\%}) were found to have mild to severe steatosis. Of the 191 total CRLM visualized by intraoperative ultrasonography, 91 (47.6{\%}) were found to be hypoechoic, 65 (34.0{\%}) were isoechoic, and 35 (18.3{\%}) were hyperechoic. In patients with steatosis, lesions were significantly more likely to be hypoechoic when compared with patients without steatosis (odds ratio, 4.17; 95{\%} confidence interval, 1.87-8.47; P=.001). Echogenicity was independent of the cause of steatosis or response to chemotherapy. Conclusions: The echogenicity of CRLM was significantly affected by the presence of liver steatosis, with decreased echogenicity and increased conspicuity of lesions despite overall poorer image quality. These findings might reinforce the usefulness of intraoperative ultrasonography in identifying additional CRLM in patients undergoing surgical therapy, even in those with fatty liver tissue.",
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AU - Torbenson, Michael S.

AU - Pawlik, Timothy M.

AU - Boctor, Emad M.

AU - Hamper, Ulrike M.

AU - Olino, Kelly

AU - Choti, Michael A.

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N2 - Objective: To investigate the association of relative tumor echogenicity and hepatic steatosis in patients undergoing resection of colorectal liver metastases (CRLM). Design: Prospective study. Setting: The Johns Hopkins Hospital. Patients: A total of 126 patients undergoing liver surgery for CRLM from January 1, 1998, through December 31, 2008, in whom 191 lesions had complete intraoperative ultrasonography images for review and adequate linked pathological data available. Main Outcome Measures: The intraoperative ultrasonography images were reviewed and scored for echogenicity (hypoechoic, isoechoic, or hyperechoic). In addition, a histopathologic review of the nontumorous liver tissue was performed, and the extent of steatosis was scored and correlated with tumor echogenicity. Results: Of the patients undergoing surgery, 49 (38.8%) were found to have mild to severe steatosis. Of the 191 total CRLM visualized by intraoperative ultrasonography, 91 (47.6%) were found to be hypoechoic, 65 (34.0%) were isoechoic, and 35 (18.3%) were hyperechoic. In patients with steatosis, lesions were significantly more likely to be hypoechoic when compared with patients without steatosis (odds ratio, 4.17; 95% confidence interval, 1.87-8.47; P=.001). Echogenicity was independent of the cause of steatosis or response to chemotherapy. Conclusions: The echogenicity of CRLM was significantly affected by the presence of liver steatosis, with decreased echogenicity and increased conspicuity of lesions despite overall poorer image quality. These findings might reinforce the usefulness of intraoperative ultrasonography in identifying additional CRLM in patients undergoing surgical therapy, even in those with fatty liver tissue.

AB - Objective: To investigate the association of relative tumor echogenicity and hepatic steatosis in patients undergoing resection of colorectal liver metastases (CRLM). Design: Prospective study. Setting: The Johns Hopkins Hospital. Patients: A total of 126 patients undergoing liver surgery for CRLM from January 1, 1998, through December 31, 2008, in whom 191 lesions had complete intraoperative ultrasonography images for review and adequate linked pathological data available. Main Outcome Measures: The intraoperative ultrasonography images were reviewed and scored for echogenicity (hypoechoic, isoechoic, or hyperechoic). In addition, a histopathologic review of the nontumorous liver tissue was performed, and the extent of steatosis was scored and correlated with tumor echogenicity. Results: Of the patients undergoing surgery, 49 (38.8%) were found to have mild to severe steatosis. Of the 191 total CRLM visualized by intraoperative ultrasonography, 91 (47.6%) were found to be hypoechoic, 65 (34.0%) were isoechoic, and 35 (18.3%) were hyperechoic. In patients with steatosis, lesions were significantly more likely to be hypoechoic when compared with patients without steatosis (odds ratio, 4.17; 95% confidence interval, 1.87-8.47; P=.001). Echogenicity was independent of the cause of steatosis or response to chemotherapy. Conclusions: The echogenicity of CRLM was significantly affected by the presence of liver steatosis, with decreased echogenicity and increased conspicuity of lesions despite overall poorer image quality. These findings might reinforce the usefulness of intraoperative ultrasonography in identifying additional CRLM in patients undergoing surgical therapy, even in those with fatty liver tissue.

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