The effect of venous obstruction in infected pedicle flap

R. Mann, Linda Phillips, J. P. Heggers, H. A. Linares, L. D. Traber, M. C. Robson

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A new model of soft-tissue infection is used to investigate the effect of the local wound environment on the septic focus. Island pedicle flaps were raised on the buttock of 24 adult ewes and multiply inoculated with Staphylococcus aureus. Flaps with bacterial inoculation, without compromise of venous outflow, showed distal necrosis (mean ± SEM percent of surface area, 25.8% ± 8.6%) and developed septic foci with bacterial counts one log less than the amount injected. Flaps with inoculation and venous outflow obstruction underwent subtotal necrosis (mean percent of surface area, 73.3% ± 11.2%) and had counts two logs higher than the nonobstructed flaps but without discrete septic foci. Flaps without inoculation, with or without venous obstruction, survived completely. Venous outflow obstruction is shown herein to potentiate tissue necrosis by raising bacterial counts in a septic focus and preventing defensive abscess formation by the host.

Original languageEnglish (US)
Pages (from-to)1177-1180
Number of pages4
JournalArchives of Surgery
Volume125
Issue number9
StatePublished - 1990
Externally publishedYes

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Necrosis
Bacterial Load
Soft Tissue Infections
Surgical Flaps
Buttocks
Abscess
Staphylococcus aureus
Wounds and Injuries

ASJC Scopus subject areas

  • Surgery

Cite this

Mann, R., Phillips, L., Heggers, J. P., Linares, H. A., Traber, L. D., & Robson, M. C. (1990). The effect of venous obstruction in infected pedicle flap. Archives of Surgery, 125(9), 1177-1180.

The effect of venous obstruction in infected pedicle flap. / Mann, R.; Phillips, Linda; Heggers, J. P.; Linares, H. A.; Traber, L. D.; Robson, M. C.

In: Archives of Surgery, Vol. 125, No. 9, 1990, p. 1177-1180.

Research output: Contribution to journalArticle

Mann, R, Phillips, L, Heggers, JP, Linares, HA, Traber, LD & Robson, MC 1990, 'The effect of venous obstruction in infected pedicle flap', Archives of Surgery, vol. 125, no. 9, pp. 1177-1180.
Mann R, Phillips L, Heggers JP, Linares HA, Traber LD, Robson MC. The effect of venous obstruction in infected pedicle flap. Archives of Surgery. 1990;125(9):1177-1180.
Mann, R. ; Phillips, Linda ; Heggers, J. P. ; Linares, H. A. ; Traber, L. D. ; Robson, M. C. / The effect of venous obstruction in infected pedicle flap. In: Archives of Surgery. 1990 ; Vol. 125, No. 9. pp. 1177-1180.
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