The effects of antibiotic-impregnated autogeneic cancellous bone graft on bone healing

Ronald Lindsey, R. Probe, T. Miclau, J. W. Alexander, S. M. Perren

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Autogeneic cancellous bone graft has been recommended as a vehicle for local antibiotic delivery. Its effect on graft incorporation, however, is unknown. The healing of defects grafted with tobramycin-impregnated cancellous bone were compared with those grafted with cancellous bone alone. Plane roentgenographs, microradiographs, bone density analyses, histologic examination, and biomechanical testing were performed on specimens throughout the course of healing. The presence of large concentrations of local tobramycin does not appear to affect the normal healing characteristics of cancellous bone graft.

Original languageEnglish (US)
Pages (from-to)303-312
Number of pages10
JournalClinical Orthopaedics and Related Research
Issue number291
StatePublished - 1993
Externally publishedYes

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Anti-Bacterial Agents
Transplants
Bone and Bones
Tobramycin
Bone Density
Cancellous Bone

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Surgery

Cite this

The effects of antibiotic-impregnated autogeneic cancellous bone graft on bone healing. / Lindsey, Ronald; Probe, R.; Miclau, T.; Alexander, J. W.; Perren, S. M.

In: Clinical Orthopaedics and Related Research, No. 291, 1993, p. 303-312.

Research output: Contribution to journalArticle

Lindsey, Ronald ; Probe, R. ; Miclau, T. ; Alexander, J. W. ; Perren, S. M. / The effects of antibiotic-impregnated autogeneic cancellous bone graft on bone healing. In: Clinical Orthopaedics and Related Research. 1993 ; No. 291. pp. 303-312.
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