The effects of antibiotic-impregnated autogeneic cancellous bone graft on bone healing

R. W. Lindsey, R. Probe, T. Miclau, J. W. Alexander, S. M. Perren

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

Autogeneic cancellous bone graft has been recommended as a vehicle for local antibiotic delivery. Its effect on graft incorporation, however, is unknown. The healing of defects grafted with tobramycin-impregnated cancellous bone were compared with those grafted with cancellous bone alone. Plane roentgenographs, microradiographs, bone density analyses, histologic examination, and biomechanical testing were performed on specimens throughout the course of healing. The presence of large concentrations of local tobramycin does not appear to affect the normal healing characteristics of cancellous bone graft.

Original languageEnglish (US)
Pages (from-to)303-312
Number of pages10
JournalClinical orthopaedics and related research
Issue number291
StatePublished - Jan 1 1993
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

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