TY - JOUR
T1 - The effects of antibiotic-impregnated autogeneic cancellous bone graft on bone healing
AU - Lindsey, R. W.
AU - Probe, R.
AU - Miclau, T.
AU - Alexander, J. W.
AU - Perren, S. M.
PY - 1993
Y1 - 1993
N2 - Autogeneic cancellous bone graft has been recommended as a vehicle for local antibiotic delivery. Its effect on graft incorporation, however, is unknown. The healing of defects grafted with tobramycin-impregnated cancellous bone were compared with those grafted with cancellous bone alone. Plane roentgenographs, microradiographs, bone density analyses, histologic examination, and biomechanical testing were performed on specimens throughout the course of healing. The presence of large concentrations of local tobramycin does not appear to affect the normal healing characteristics of cancellous bone graft.
AB - Autogeneic cancellous bone graft has been recommended as a vehicle for local antibiotic delivery. Its effect on graft incorporation, however, is unknown. The healing of defects grafted with tobramycin-impregnated cancellous bone were compared with those grafted with cancellous bone alone. Plane roentgenographs, microradiographs, bone density analyses, histologic examination, and biomechanical testing were performed on specimens throughout the course of healing. The presence of large concentrations of local tobramycin does not appear to affect the normal healing characteristics of cancellous bone graft.
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U2 - 10.1097/00003086-199306000-00035
DO - 10.1097/00003086-199306000-00035
M3 - Article
C2 - 8504612
AN - SCOPUS:0027152002
SN - 0009-921X
VL - 291
SP - 303
EP - 312
JO - Clinical orthopaedics and related research
JF - Clinical orthopaedics and related research
ER -