The effects of burn injury on the acute phase response

Z. F. Xia, M. I. Coolbaugh, F. He, David Herndon, John Papaconstantinou

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The time course of changes in the levels of acute-phase-reactant (APR) mRNAs in different tissues of rats with a 10% or a 60% total-body-surface- area (TBSA) burn and the relationship between the induction of APRs and the host's tolerance to thermal injury were studied. The acute phase response in a LPS-induced inflammation model and a burn-plus-LPS model were compared. The results of this study indicated that (1) the major site of APR synthesis is the liver; (2) even a small surface burn injury can elicit a rapid acute phase response, but the intensity of APR expression increases with the severity of the burn; (3) the down regulation of albumin mRNA, which is characteristic of the acute phase response, does not occur even though transferrin (Trf) mRNA levels are significantly decreased; (4) the resistant strain of inbred rats showed higher levels of α1-antitrypsin (AT) mRNA before and after burn injury, indicating its contribution to the host's tolerance to thermal injury; (5) the increases in α1-acid glycoprotein (AGP) and AT expressions are limited in the burn-plus-LPS rat model compared with either the burn model or LPS-stimulated model alone.

Original languageEnglish (US)
Pages (from-to)245-251
Number of pages7
JournalJournal of Trauma
Volume32
Issue number2
StatePublished - 1992

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Acute-Phase Reaction
Acute-Phase Proteins
Messenger RNA
Wounds and Injuries
Burns
Hot Temperature
Inbred Strains Rats
Body Surface Area
Transferrin
Albumins
Glycoproteins
Down-Regulation
Inflammation
Acids
Liver

ASJC Scopus subject areas

  • Surgery

Cite this

Xia, Z. F., Coolbaugh, M. I., He, F., Herndon, D., & Papaconstantinou, J. (1992). The effects of burn injury on the acute phase response. Journal of Trauma, 32(2), 245-251.

The effects of burn injury on the acute phase response. / Xia, Z. F.; Coolbaugh, M. I.; He, F.; Herndon, David; Papaconstantinou, John.

In: Journal of Trauma, Vol. 32, No. 2, 1992, p. 245-251.

Research output: Contribution to journalArticle

Xia, ZF, Coolbaugh, MI, He, F, Herndon, D & Papaconstantinou, J 1992, 'The effects of burn injury on the acute phase response', Journal of Trauma, vol. 32, no. 2, pp. 245-251.
Xia ZF, Coolbaugh MI, He F, Herndon D, Papaconstantinou J. The effects of burn injury on the acute phase response. Journal of Trauma. 1992;32(2):245-251.
Xia, Z. F. ; Coolbaugh, M. I. ; He, F. ; Herndon, David ; Papaconstantinou, John. / The effects of burn injury on the acute phase response. In: Journal of Trauma. 1992 ; Vol. 32, No. 2. pp. 245-251.
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