The effects of ritodrine on prostaglandin metabolite concentrations in the blood of pregnant baboons

Gary Hankins, D. M. Strickland, J. C. Hauth, T. J. Kuehl, M. D. Mitchell

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

To investigate the relationship between beta sympathomimetic drugs and prostaglandins, we measured prostaglandin metabolites in the plasma of pregnant baboons that were given the drug ritodrine. Animals were at a mean gestation of 120 days, which is equivalent to 27 weeks in women. Ritodrine was infused i.v. at a rate of 23 μg/min or 80 μg/min for 4 h. Plasma concentrations of 13,14-dihydro-15-keto-prostaglandin F (PGFM), 11-deoxy-13,14-dihydro-15-keto-11,16-cyclo-prostaglandin E2 (PGEM-11), and 6-keto-prostaglandin-F (6-keto-PGF) were determined as indicators of the precursors, prostaglandin F, prostaglandin E2, and prostacyclin (PGI2), respectively. At the 23 μg/min ritodrine infusion rate plasma levels of 6-keto-PGF were decreased by 51% (± 15%) in the animals receiving the drug (p < 0.005) whereas corresponding levels in control animals did not differ significantly from pre-infusion levels. At the 80 μg/min ritodrine infusion rate, the plasma levels of 6-keto-PGF decreased by 66% (± 18%) compared with pre-infusion levels (p < 0.001) but again the levels in control animals were not changed significantly. Plasma levels of PGFM and PGEM-11 in animals during ritodrine treatment did not differ significantly from baseline values.

Original languageEnglish (US)
Pages (from-to)21-26
Number of pages6
JournalArchives of Gynecology
Volume234
Issue number1
DOIs
StatePublished - Nov 1983
Externally publishedYes

Fingerprint

Ritodrine
Papio
Prostaglandins
Dinoprost
Epoprostenol
Dinoprostone
Sympathomimetics
Pharmaceutical Preparations
Pregnancy
prostaglandin F1

Keywords

  • Baboons
  • Pregnancy
  • Prostacyclin
  • Prostaglandins
  • Ritodrine

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Medicine(all)

Cite this

Hankins, G., Strickland, D. M., Hauth, J. C., Kuehl, T. J., & Mitchell, M. D. (1983). The effects of ritodrine on prostaglandin metabolite concentrations in the blood of pregnant baboons. Archives of Gynecology, 234(1), 21-26. https://doi.org/10.1007/BF02114720

The effects of ritodrine on prostaglandin metabolite concentrations in the blood of pregnant baboons. / Hankins, Gary; Strickland, D. M.; Hauth, J. C.; Kuehl, T. J.; Mitchell, M. D.

In: Archives of Gynecology, Vol. 234, No. 1, 11.1983, p. 21-26.

Research output: Contribution to journalArticle

Hankins, G, Strickland, DM, Hauth, JC, Kuehl, TJ & Mitchell, MD 1983, 'The effects of ritodrine on prostaglandin metabolite concentrations in the blood of pregnant baboons', Archives of Gynecology, vol. 234, no. 1, pp. 21-26. https://doi.org/10.1007/BF02114720
Hankins, Gary ; Strickland, D. M. ; Hauth, J. C. ; Kuehl, T. J. ; Mitchell, M. D. / The effects of ritodrine on prostaglandin metabolite concentrations in the blood of pregnant baboons. In: Archives of Gynecology. 1983 ; Vol. 234, No. 1. pp. 21-26.
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