The effects of ritodrine on prostaglandin metabolite concentrations in the blood of pregnant baboons

G. D.V. Hankins, D. M. Strickland, J. C. Hauth, T. J. Kuehl, M. D. Mitchell

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Abstract

To investigate the relationship between beta sympathomimetic drugs and prostaglandins, we measured prostaglandin metabolites in the plasma of pregnant baboons that were given the drug ritodrine. Animals were at a mean gestation of 120 days, which is equivalent to 27 weeks in women. Ritodrine was infused i.v. at a rate of 23 μg/min or 80 μg/min for 4 h. Plasma concentrations of 13,14-dihydro-15-keto-prostaglandin F (PGFM), 11-deoxy-13,14-dihydro-15-keto-11,16-cyclo-prostaglandin E2 (PGEM-11), and 6-keto-prostaglandin-F (6-keto-PGF) were determined as indicators of the precursors, prostaglandin F, prostaglandin E2, and prostacyclin (PGI2), respectively. At the 23 μg/min ritodrine infusion rate plasma levels of 6-keto-PGF were decreased by 51% (± 15%) in the animals receiving the drug (p < 0.005) whereas corresponding levels in control animals did not differ significantly from pre-infusion levels. At the 80 μg/min ritodrine infusion rate, the plasma levels of 6-keto-PGF decreased by 66% (± 18%) compared with pre-infusion levels (p < 0.001) but again the levels in control animals were not changed significantly. Plasma levels of PGFM and PGEM-11 in animals during ritodrine treatment did not differ significantly from baseline values.

Original languageEnglish (US)
Pages (from-to)21-26
Number of pages6
JournalArchives of Gynecology
Volume234
Issue number1
DOIs
StatePublished - Nov 1 1983

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Keywords

  • Baboons
  • Pregnancy
  • Prostacyclin
  • Prostaglandins
  • Ritodrine

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Hankins, G. D. V., Strickland, D. M., Hauth, J. C., Kuehl, T. J., & Mitchell, M. D. (1983). The effects of ritodrine on prostaglandin metabolite concentrations in the blood of pregnant baboons. Archives of Gynecology, 234(1), 21-26. https://doi.org/10.1007/BF02114720