The efficient synthesis of isotopically labeled peptide-derived Amadori products and their characterization

Katarzyna Kapczyńska; Piotr Stefanowicz; Łukasz Jaremko; Mariusz Jaremko; Alicja Kluczyk; Zbigniew Szewczuk

doi:10.1007/s00726-010-0714-0

The efficient synthesis of isotopically labeled peptide-derived Amadori products and their characterization

Katarzyna Kapczyńska
, Piotr Stefanowicz
, Łukasz Jaremko
, Mariusz Jaremko
, Alicja Kluczyk
, Zbigniew Szewczuk

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Protein glycation is often a cause of diabetes-associated complications. The isotopically labeled peptide-derived Amadori products may serve as standards for quantitative determination of the glycated proteins. In this paper, we discussed various approaches to the synthesis of Amadori products labeled selectively with stable isotopes ²H, ¹³C and ¹⁸O.

Original language	English (US)
Pages (from-to)	923-932
Number of pages	10
Journal	Amino Acids
Volume	40
Issue number	3
DOIs	https://doi.org/10.1007/s00726-010-0714-0
State	Published - Mar 2011
Externally published	Yes

Keywords

C
O
H
Amadori rearrangement
Fructose
Glucose
Glycation
Isotopes
Labeling
Microwave synthesis
NMR studies
Non-enzymatic protein modifications
Peptides
Regioselective

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Clinical Biochemistry

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10.1007/s00726-010-0714-0

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title = "The efficient synthesis of isotopically labeled peptide-derived Amadori products and their characterization",

abstract = "Protein glycation is often a cause of diabetes-associated complications. The isotopically labeled peptide-derived Amadori products may serve as standards for quantitative determination of the glycated proteins. In this paper, we discussed various approaches to the synthesis of Amadori products labeled selectively with stable isotopes 2H, 13C and 18O.",

keywords = "C, O, H, Amadori rearrangement, Fructose, Glucose, Glycation, Isotopes, Labeling, Microwave synthesis, NMR studies, Non-enzymatic protein modifications, Peptides, Regioselective",

author = "Katarzyna Kapczy{\'n}ska and Piotr Stefanowicz and {\L}ukasz Jaremko and Mariusz Jaremko and Alicja Kluczyk and Zbigniew Szewczuk",

year = "2011",

month = mar,

doi = "10.1007/s00726-010-0714-0",

language = "English (US)",

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pages = "923--932",

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AU - Kapczyńska, Katarzyna

AU - Stefanowicz, Piotr

AU - Jaremko, Łukasz

AU - Jaremko, Mariusz

AU - Kluczyk, Alicja

AU - Szewczuk, Zbigniew

PY - 2011/3

Y1 - 2011/3

N2 - Protein glycation is often a cause of diabetes-associated complications. The isotopically labeled peptide-derived Amadori products may serve as standards for quantitative determination of the glycated proteins. In this paper, we discussed various approaches to the synthesis of Amadori products labeled selectively with stable isotopes 2H, 13C and 18O.

AB - Protein glycation is often a cause of diabetes-associated complications. The isotopically labeled peptide-derived Amadori products may serve as standards for quantitative determination of the glycated proteins. In this paper, we discussed various approaches to the synthesis of Amadori products labeled selectively with stable isotopes 2H, 13C and 18O.

KW - C

KW - O

KW - H

KW - Amadori rearrangement

KW - Fructose

KW - Glucose

KW - Glycation

KW - Isotopes

KW - Labeling

KW - Microwave synthesis

KW - NMR studies

KW - Non-enzymatic protein modifications

KW - Peptides

KW - Regioselective

UR - https://www.scopus.com/pages/publications/79954442440

UR - https://www.scopus.com/pages/publications/79954442440#tab=citedBy

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DO - 10.1007/s00726-010-0714-0

M3 - Article

C2 - 20734213

AN - SCOPUS:79954442440

SN - 0939-4451

VL - 40

SP - 923

EP - 932

JO - Amino Acids

JF - Amino Acids

IS - 3

ER -

The efficient synthesis of isotopically labeled peptide-derived Amadori products and their characterization

Abstract

Keywords

ASJC Scopus subject areas

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