The endogenous GABA bioactivity of camel, bovine, goat and human milks

Agenor Limon-Ruiz, Jose Luis Gallegos-Perez, Jorge M. Reyes-Ruiz, Mohammad A. Aljohi, Ali S. Alshanqeeti, Ricardo Miledi

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

GABA orally administered has several beneficial effects on health, including the regulation of hyperglycaemic states in humans. Those effects are similar to the effects reported for camel milk (CMk); however, it is not known whether compounds with GABAergic activity are present in milk from camels or other species. We determined CMk free-GABA concentration by LS/MS and its bioactivity on human GABA receptors. We found that camel and goat milks have significantly more bioavailable GABA than cow and human milks and are able to activate GABAρ receptors. The relationship between GABA and taurine concentrations suggests that whole camel milk may be more efficient to activate GABAρ1 receptors than goat milk. Because GABAρ receptors are normally found in enteroendocrine cells in the lumen of the digestive tract, these results suggest that GABA in camel and goat milk may participate in GABA-modulated functions of enteroendocrine cells in the GI lumen.

Original languageEnglish (US)
Pages (from-to)481-487
Number of pages7
JournalFood Chemistry
Volume145
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

camel milk
Camelus
gamma-aminobutyric acid
goat milk
Human Milk
breast milk
Bioactivity
Goats
gamma-Aminobutyric Acid
Milk
milk
GABA Receptors
Enteroendocrine Cells
taurine
camels
Taurine
digestive tract
Gastrointestinal Tract
cells
Health

Keywords

  • Diary
  • Gut
  • Hyperglycaemia
  • Membrane receptors

ASJC Scopus subject areas

  • Food Science
  • Analytical Chemistry
  • Medicine(all)

Cite this

Limon-Ruiz, A., Gallegos-Perez, J. L., Reyes-Ruiz, J. M., Aljohi, M. A., Alshanqeeti, A. S., & Miledi, R. (2014). The endogenous GABA bioactivity of camel, bovine, goat and human milks. Food Chemistry, 145, 481-487. https://doi.org/10.1016/j.foodchem.2013.08.058

The endogenous GABA bioactivity of camel, bovine, goat and human milks. / Limon-Ruiz, Agenor; Gallegos-Perez, Jose Luis; Reyes-Ruiz, Jorge M.; Aljohi, Mohammad A.; Alshanqeeti, Ali S.; Miledi, Ricardo.

In: Food Chemistry, Vol. 145, 01.01.2014, p. 481-487.

Research output: Contribution to journalArticle

Limon-Ruiz, A, Gallegos-Perez, JL, Reyes-Ruiz, JM, Aljohi, MA, Alshanqeeti, AS & Miledi, R 2014, 'The endogenous GABA bioactivity of camel, bovine, goat and human milks', Food Chemistry, vol. 145, pp. 481-487. https://doi.org/10.1016/j.foodchem.2013.08.058
Limon-Ruiz A, Gallegos-Perez JL, Reyes-Ruiz JM, Aljohi MA, Alshanqeeti AS, Miledi R. The endogenous GABA bioactivity of camel, bovine, goat and human milks. Food Chemistry. 2014 Jan 1;145:481-487. https://doi.org/10.1016/j.foodchem.2013.08.058
Limon-Ruiz, Agenor ; Gallegos-Perez, Jose Luis ; Reyes-Ruiz, Jorge M. ; Aljohi, Mohammad A. ; Alshanqeeti, Ali S. ; Miledi, Ricardo. / The endogenous GABA bioactivity of camel, bovine, goat and human milks. In: Food Chemistry. 2014 ; Vol. 145. pp. 481-487.
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