The endogenous GABA bioactivity of camel, bovine, goat and human milks

Agenor Limon-Ruiz, Jose Luis Gallegos-Perez, Jorge M. Reyes-Ruiz, Mohammad A. Aljohi, Ali S. Alshanqeeti, Ricardo Miledi

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

GABA orally administered has several beneficial effects on health, including the regulation of hyperglycaemic states in humans. Those effects are similar to the effects reported for camel milk (CMk); however, it is not known whether compounds with GABAergic activity are present in milk from camels or other species. We determined CMk free-GABA concentration by LS/MS and its bioactivity on human GABA receptors. We found that camel and goat milks have significantly more bioavailable GABA than cow and human milks and are able to activate GABAρ receptors. The relationship between GABA and taurine concentrations suggests that whole camel milk may be more efficient to activate GABAρ1 receptors than goat milk. Because GABAρ receptors are normally found in enteroendocrine cells in the lumen of the digestive tract, these results suggest that GABA in camel and goat milk may participate in GABA-modulated functions of enteroendocrine cells in the GI lumen.

Original languageEnglish (US)
Pages (from-to)481-487
Number of pages7
JournalFood Chemistry
Volume145
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Keywords

  • Diary
  • Gut
  • Hyperglycaemia
  • Membrane receptors

ASJC Scopus subject areas

  • Food Science
  • Analytical Chemistry
  • Medicine(all)

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  • Cite this

    Limon-Ruiz, A., Gallegos-Perez, J. L., Reyes-Ruiz, J. M., Aljohi, M. A., Alshanqeeti, A. S., & Miledi, R. (2014). The endogenous GABA bioactivity of camel, bovine, goat and human milks. Food Chemistry, 145, 481-487. https://doi.org/10.1016/j.foodchem.2013.08.058