The epidemiology of depression and the evolution of treatment

Robert M.A. Hirschfeld

Research output: Contribution to journalReview articlepeer-review

77 Scopus citations


Depression is a prevalent and pernicious disorder. About 1 in 5 US adults have at least 1 lifetime episode of major depression. Of those with depression, the majority will relapse over the long-term and many will have poor mental health outcomes and psychosocial disabilities. Over the past century, a range of treatments, including medications with varying mechanisms of action, have been developed to manage depression. Treatments from seizure therapies to an array of medications-amphetamine, tricyclic antidepressants, monoamine oxidase inhibitors, mixed-action antidepressants, selective serotonin reuptake inhibitors, and dual reuptake inhibitors - have evolved.

Original languageEnglish (US)
Pages (from-to)5-9
Number of pages5
JournalJournal of Clinical Psychiatry
Issue numberSUPPL. 1
StatePublished - 2012

ASJC Scopus subject areas

  • Psychiatry and Mental health


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