TY - JOUR
T1 - The evaluation of mutagenicities of 19 structurally related aromatic amines and acetamides in Salmonella typhimurium TA98 and TA100
AU - Connor, Thomas H.
AU - Sadagopa Ramanujam, V. M.
AU - Rinkus, Stephen J.
AU - S. Legator; Norman M. Trieff, Marvin
N1 - Funding Information:
We are happy to acknowledge the financial support for this research from the Robert A. Welch Foundation Grant H-416 (to Dr. N.M. Trieff), the Department of Energy Grant DE-AS05-78-EV06023 and the United States Environmental Protection Agency Grant 4440414-807820-01 (both to Dr. M.S. Legator). We also thank Mrs. Elizabeth Thompson for typing this manuscript.
PY - 1983/7
Y1 - 1983/7
N2 - 19 aromatic amines were assayed for mutagenicity using Salmonella typhimurium strains TA98 and TA100 with and without the addition of S9 from Aroclor-1254-induced rat liver. These included: naphthalenes (1-amino-, 1-acetamido-, 2-amino-, 2-acetamido-, 1-amino-4-nitro- and 2-amino-1-nitro-), biphenyls (2-amino-, 2-acetamido-, 4-amino- and 4-acetamido-), fluorenes (2-amino- and 2-acetamido-), anthracenes (1-amino-, 1-acetamido-, 2-amino- and 2-acetamido-), 3-aminofluoranthene, 1-aminopyrene and 6-aminochrysene. None of the compounds were mutagenic when tested without S9. With S9, 15 of 19 were mutagenic for TA98 and 16 of the 19 were mutagenic for TA100. Overall, 2-aminoanthracene was the most potent mutagen. When compared to the parent amines, the respective acetamido derivatives were consistently less mutagenic.
AB - 19 aromatic amines were assayed for mutagenicity using Salmonella typhimurium strains TA98 and TA100 with and without the addition of S9 from Aroclor-1254-induced rat liver. These included: naphthalenes (1-amino-, 1-acetamido-, 2-amino-, 2-acetamido-, 1-amino-4-nitro- and 2-amino-1-nitro-), biphenyls (2-amino-, 2-acetamido-, 4-amino- and 4-acetamido-), fluorenes (2-amino- and 2-acetamido-), anthracenes (1-amino-, 1-acetamido-, 2-amino- and 2-acetamido-), 3-aminofluoranthene, 1-aminopyrene and 6-aminochrysene. None of the compounds were mutagenic when tested without S9. With S9, 15 of 19 were mutagenic for TA98 and 16 of the 19 were mutagenic for TA100. Overall, 2-aminoanthracene was the most potent mutagen. When compared to the parent amines, the respective acetamido derivatives were consistently less mutagenic.
UR - https://www.scopus.com/pages/publications/0020607541
UR - https://www.scopus.com/pages/publications/0020607541#tab=citedBy
U2 - 10.1016/0165-1218(83)90115-5
DO - 10.1016/0165-1218(83)90115-5
M3 - Article
C2 - 6346086
AN - SCOPUS:0020607541
SN - 0165-1218
VL - 118
SP - 49
EP - 59
JO - Mutation Research/Genetic Toxicology
JF - Mutation Research/Genetic Toxicology
IS - 1-2
ER -