The evolutionary genetics and emergence of avian influenza viruses in wild birds

Vivien G. Dugan, Rubing Chen, David J. Spiro, Naomi Sengamalay, Jennifer Zaborsky, Elodie Ghedin, Jacqueline Nolting, David E. Swayne, Jonathan A. Runstadler, George M. Happ, Dennis A. Senne, Ruixue Wang, Richard D. Slemons, Edward C. Holmes, Jeffery K. Taubenberger

Research output: Contribution to journalArticle

242 Citations (Scopus)

Abstract

We surveyed the genetic diversity among avian influenza virus (AIV) in wild birds, comprising 167 complete viral genomes from 14 bird species sampled in four locations across the United States. These isolates represented 29 type A influenza virus hemagglutinin (HA) and neuraminidase (NA) subtype combinations, with up to 26% of isolates showing evidence of mixed subtype infection. Through a phylogenetic analysis of the largest data set of AIV genomes compiled to date, we were able to document a remarkably high rate of genome reassortment, with no clear pattern of gene segment association and occasional inter-hemisphere gene segment migration and reassortment. From this, we propose that AIV in wild birds forms transient "genome constellations," continually reshuffled by reassortment, in contrast to the spread of a limited number of stable genome constellations that characterizes the evolution of mammalian-adapted influenza A viruses.

Original languageEnglish (US)
Article numbere1000076
JournalPLoS Pathogens
Volume4
Issue number5
DOIs
StatePublished - May 2008
Externally publishedYes

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Influenza in Birds
Orthomyxoviridae
Birds
Genome
Influenza A virus
Viral Genome
Hemagglutinins
Coinfection
Genes

ASJC Scopus subject areas

  • Microbiology
  • Parasitology
  • Virology
  • Immunology
  • Genetics
  • Molecular Biology

Cite this

Dugan, V. G., Chen, R., Spiro, D. J., Sengamalay, N., Zaborsky, J., Ghedin, E., ... Taubenberger, J. K. (2008). The evolutionary genetics and emergence of avian influenza viruses in wild birds. PLoS Pathogens, 4(5), [e1000076]. https://doi.org/10.1371/journal.ppat.1000076

The evolutionary genetics and emergence of avian influenza viruses in wild birds. / Dugan, Vivien G.; Chen, Rubing; Spiro, David J.; Sengamalay, Naomi; Zaborsky, Jennifer; Ghedin, Elodie; Nolting, Jacqueline; Swayne, David E.; Runstadler, Jonathan A.; Happ, George M.; Senne, Dennis A.; Wang, Ruixue; Slemons, Richard D.; Holmes, Edward C.; Taubenberger, Jeffery K.

In: PLoS Pathogens, Vol. 4, No. 5, e1000076, 05.2008.

Research output: Contribution to journalArticle

Dugan, VG, Chen, R, Spiro, DJ, Sengamalay, N, Zaborsky, J, Ghedin, E, Nolting, J, Swayne, DE, Runstadler, JA, Happ, GM, Senne, DA, Wang, R, Slemons, RD, Holmes, EC & Taubenberger, JK 2008, 'The evolutionary genetics and emergence of avian influenza viruses in wild birds', PLoS Pathogens, vol. 4, no. 5, e1000076. https://doi.org/10.1371/journal.ppat.1000076
Dugan VG, Chen R, Spiro DJ, Sengamalay N, Zaborsky J, Ghedin E et al. The evolutionary genetics and emergence of avian influenza viruses in wild birds. PLoS Pathogens. 2008 May;4(5). e1000076. https://doi.org/10.1371/journal.ppat.1000076
Dugan, Vivien G. ; Chen, Rubing ; Spiro, David J. ; Sengamalay, Naomi ; Zaborsky, Jennifer ; Ghedin, Elodie ; Nolting, Jacqueline ; Swayne, David E. ; Runstadler, Jonathan A. ; Happ, George M. ; Senne, Dennis A. ; Wang, Ruixue ; Slemons, Richard D. ; Holmes, Edward C. ; Taubenberger, Jeffery K. / The evolutionary genetics and emergence of avian influenza viruses in wild birds. In: PLoS Pathogens. 2008 ; Vol. 4, No. 5.
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