The expanding spectrum of eschar-associated rickettsioses in the United States

W. Chad Cragun, Brenda L. Bartlett, Michael W. Ellis, Aaron Z. Hoover, Stephen K. Tyring, Natalia Mendoza, Todd J. Vento, William L. Nicholson, Marina E. Eremeeva, Juan P. Olano, Ronald P. Rapini, Christopher D. Paddock

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


Background: Until recently, Rickettsia rickettsii was the only substantiated cause of tick-borne spotted fever group (SFG) rickettsiosis in humans in the United States. Rickettsia parkeri, originally thought to be nonpathogenic in humans, was recently proved to be another cause of tickborne SFG rickettsiosis. Observations:Wereport 3 cases of SFG rickettsiosis and discuss the epidemiology, clinical presentation, histopathologic features, and laboratory findings that support confirmed or probable diagnoses of R parkeri infection and describe the expanding list of eschar-associated SFG rickettsioses recognized in US patients. Conclusions: The SFG rickettsioses share many clinical manifestations and extensive antigenic cross-reactivity that may hamper specific confirmation of the causative agent.

Original languageEnglish (US)
Pages (from-to)641-648
Number of pages8
JournalArchives of Dermatology
Issue number6
StatePublished - Jun 2010

ASJC Scopus subject areas

  • Dermatology


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