The expression of Fhit protein is related inversely to disease progression in patients with breast carcinoma

Zoran Gatalica, Subodh M. Lele, B. Alan Rampy, Brent A. Norris

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

BACKGROUND. The FHIT gene, located at human chromosome 3p14.2, frequently is deleted in a number of human tumors, including breast carcinoma. Its protein product (Fhit) is presumed to have tumor suppressor function. Loss of expression of a tumor suppressor gene is an important step in tumor progression from premalignant, to in situ, to invasive carcinoma. METHODS. In the current study, Fhit expression was examined in invasive carcinomas and in epithelial lesions representing stages of carcinoma progression in 50 mastectomy specimens using immunohistochemical methods. RESULTS. Normal ductal and lobular epithelium consistently and strongly expressed Fhit. A complete loss of or a significant reduction in Fhit expression was observed in 72% of breast carcinomas. A statistically significant, negative correlation in Fhit expression among the stages of disease progression in Fhit negative breast carcinomas was observed (normal epithelium > hyperplasia > atypical hyperplasia and carcinoma in situ > invasive carcinoma), whereas no loss of Fhit expression in precursor lesions was observed in Fhit positive tumors. CONCLUSIONS. These observations are consistent with the observed role of FHIT as a tumor suppressor gene in the pathogenesis of specific subsets of carcinomas. (C) 2000 American Cancer Society.

Original languageEnglish (US)
Pages (from-to)1378-1383
Number of pages6
JournalCancer
Volume88
Issue number6
DOIs
StatePublished - Mar 15 2000

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Disease Progression
Breast Neoplasms
Carcinoma
Proteins
Tumor Suppressor Genes
Hyperplasia
Neoplasms
Epithelium
Mastectomy
Carcinoma in Situ
Human Chromosomes
Genes

Keywords

  • Breast
  • Carcinoma
  • Fhit
  • Hyperplasia

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

The expression of Fhit protein is related inversely to disease progression in patients with breast carcinoma. / Gatalica, Zoran; Lele, Subodh M.; Rampy, B. Alan; Norris, Brent A.

In: Cancer, Vol. 88, No. 6, 15.03.2000, p. 1378-1383.

Research output: Contribution to journalArticle

Gatalica, Zoran ; Lele, Subodh M. ; Rampy, B. Alan ; Norris, Brent A. / The expression of Fhit protein is related inversely to disease progression in patients with breast carcinoma. In: Cancer. 2000 ; Vol. 88, No. 6. pp. 1378-1383.
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N2 - BACKGROUND. The FHIT gene, located at human chromosome 3p14.2, frequently is deleted in a number of human tumors, including breast carcinoma. Its protein product (Fhit) is presumed to have tumor suppressor function. Loss of expression of a tumor suppressor gene is an important step in tumor progression from premalignant, to in situ, to invasive carcinoma. METHODS. In the current study, Fhit expression was examined in invasive carcinomas and in epithelial lesions representing stages of carcinoma progression in 50 mastectomy specimens using immunohistochemical methods. RESULTS. Normal ductal and lobular epithelium consistently and strongly expressed Fhit. A complete loss of or a significant reduction in Fhit expression was observed in 72% of breast carcinomas. A statistically significant, negative correlation in Fhit expression among the stages of disease progression in Fhit negative breast carcinomas was observed (normal epithelium > hyperplasia > atypical hyperplasia and carcinoma in situ > invasive carcinoma), whereas no loss of Fhit expression in precursor lesions was observed in Fhit positive tumors. CONCLUSIONS. These observations are consistent with the observed role of FHIT as a tumor suppressor gene in the pathogenesis of specific subsets of carcinomas. (C) 2000 American Cancer Society.

AB - BACKGROUND. The FHIT gene, located at human chromosome 3p14.2, frequently is deleted in a number of human tumors, including breast carcinoma. Its protein product (Fhit) is presumed to have tumor suppressor function. Loss of expression of a tumor suppressor gene is an important step in tumor progression from premalignant, to in situ, to invasive carcinoma. METHODS. In the current study, Fhit expression was examined in invasive carcinomas and in epithelial lesions representing stages of carcinoma progression in 50 mastectomy specimens using immunohistochemical methods. RESULTS. Normal ductal and lobular epithelium consistently and strongly expressed Fhit. A complete loss of or a significant reduction in Fhit expression was observed in 72% of breast carcinomas. A statistically significant, negative correlation in Fhit expression among the stages of disease progression in Fhit negative breast carcinomas was observed (normal epithelium > hyperplasia > atypical hyperplasia and carcinoma in situ > invasive carcinoma), whereas no loss of Fhit expression in precursor lesions was observed in Fhit positive tumors. CONCLUSIONS. These observations are consistent with the observed role of FHIT as a tumor suppressor gene in the pathogenesis of specific subsets of carcinomas. (C) 2000 American Cancer Society.

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KW - Hyperplasia

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