The first reported case of double trisomy 10 and 20 in a product of conception

Joshua Fernandez De La Vega, Arian Pourmehdi Lahiji, Caitlin Raymond, Song Han, Harshwardhan Thaker, Jianli Dong

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Double trisomies are rare findings among products of conception and are often lethal to the developing embryo or fetus. Methods: Here we describe a double trisomy case with symptoms of threatened miscarriage at 9 weeks gestation. Ultrasound revealed an anembryonic pregnancy. Pregnancy was terminated by dilation and curettage at gestational age 11 weeks and 6 days. Histologic examination and chromosome microarray were performed on a formalin-fixed product of conception (POC) sample to identify the cause of the anembryonic pregnancy. Results: Chromosome microarray analysis revealed a female chromosome complement with double trisomies 10 and 20, arr(10,20)x3, consistent with a karyotype of 48,XX,+10,+20. Conclusion: To the best of our knowledge, this is the first reported case of double trisomy 10 and 20 in a POC. Due to nonspecific histopathological findings, chromosomal microarray is a powerful tool in identifying and differentiating chromosomal aneuploidies.

Original languageEnglish (US)
Pages (from-to)245-248
Number of pages4
JournalLab Medicine
Volume55
Issue number2
DOIs
StatePublished - Mar 1 2024
Externally publishedYes

Keywords

  • chromosome microarray
  • double trisomy 10 and 20
  • genetics
  • genomics
  • laboratory genetics
  • product of conception
  • triplosensitivity

ASJC Scopus subject areas

  • General Medicine

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