The generation and conduction of activity in smooth muscle.

E. E. Daniel, S. Sarna

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Smooth muscle, especially gastrointestinal smooth muscle, spontaneously generates oscillatory electrical activity that can control contractions in time and space by altering excitability. The origin and ionic mechanisms underlying these electrical control activities are still controversial, but they behave as coupled relaxation oscillators and they control muscle excitability. Normally, contractions are produced by the addition, during the depolarized phase of the oscillations, of further depolarization by acetylcholine or other means. Pharmacologists who wish to study drug actions on such muscles must be aware of the possibility that drug effects may be determined by these oscillations and may influence contractions by affecting these oscillations as well as by releasing, mimicking, or inhibiting the effects of nerve mediators or by affecting excitation-contraction coupling. Also the use of simplified organ bath preparations may eliminate or alter these control potentials so that results in vitro may not apply in vivo.

Original languageEnglish (US)
Pages (from-to)145-166
Number of pages22
JournalAnnual Review of Pharmacology and Toxicology
Volume18
StatePublished - 1978
Externally publishedYes

Fingerprint

Smooth Muscle
Muscle
Excitation Contraction Coupling
Muscles
Baths
Pharmaceutical Preparations
Acetylcholine
Relaxation oscillators
Depolarization
In Vitro Techniques

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

The generation and conduction of activity in smooth muscle. / Daniel, E. E.; Sarna, S.

In: Annual Review of Pharmacology and Toxicology, Vol. 18, 1978, p. 145-166.

Research output: Contribution to journalArticle

@article{ca53324d1e184b1d914fa9f4da9ddd99,
title = "The generation and conduction of activity in smooth muscle.",
abstract = "Smooth muscle, especially gastrointestinal smooth muscle, spontaneously generates oscillatory electrical activity that can control contractions in time and space by altering excitability. The origin and ionic mechanisms underlying these electrical control activities are still controversial, but they behave as coupled relaxation oscillators and they control muscle excitability. Normally, contractions are produced by the addition, during the depolarized phase of the oscillations, of further depolarization by acetylcholine or other means. Pharmacologists who wish to study drug actions on such muscles must be aware of the possibility that drug effects may be determined by these oscillations and may influence contractions by affecting these oscillations as well as by releasing, mimicking, or inhibiting the effects of nerve mediators or by affecting excitation-contraction coupling. Also the use of simplified organ bath preparations may eliminate or alter these control potentials so that results in vitro may not apply in vivo.",
author = "Daniel, {E. E.} and S. Sarna",
year = "1978",
language = "English (US)",
volume = "18",
pages = "145--166",
journal = "Annual Review of Pharmacology and Toxicology",
issn = "0362-1642",
publisher = "Annual Reviews Inc.",

}

TY - JOUR

T1 - The generation and conduction of activity in smooth muscle.

AU - Daniel, E. E.

AU - Sarna, S.

PY - 1978

Y1 - 1978

N2 - Smooth muscle, especially gastrointestinal smooth muscle, spontaneously generates oscillatory electrical activity that can control contractions in time and space by altering excitability. The origin and ionic mechanisms underlying these electrical control activities are still controversial, but they behave as coupled relaxation oscillators and they control muscle excitability. Normally, contractions are produced by the addition, during the depolarized phase of the oscillations, of further depolarization by acetylcholine or other means. Pharmacologists who wish to study drug actions on such muscles must be aware of the possibility that drug effects may be determined by these oscillations and may influence contractions by affecting these oscillations as well as by releasing, mimicking, or inhibiting the effects of nerve mediators or by affecting excitation-contraction coupling. Also the use of simplified organ bath preparations may eliminate or alter these control potentials so that results in vitro may not apply in vivo.

AB - Smooth muscle, especially gastrointestinal smooth muscle, spontaneously generates oscillatory electrical activity that can control contractions in time and space by altering excitability. The origin and ionic mechanisms underlying these electrical control activities are still controversial, but they behave as coupled relaxation oscillators and they control muscle excitability. Normally, contractions are produced by the addition, during the depolarized phase of the oscillations, of further depolarization by acetylcholine or other means. Pharmacologists who wish to study drug actions on such muscles must be aware of the possibility that drug effects may be determined by these oscillations and may influence contractions by affecting these oscillations as well as by releasing, mimicking, or inhibiting the effects of nerve mediators or by affecting excitation-contraction coupling. Also the use of simplified organ bath preparations may eliminate or alter these control potentials so that results in vitro may not apply in vivo.

UR - http://www.scopus.com/inward/record.url?scp=0017912570&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017912570&partnerID=8YFLogxK

M3 - Article

C2 - 348057

AN - SCOPUS:0017912570

VL - 18

SP - 145

EP - 166

JO - Annual Review of Pharmacology and Toxicology

JF - Annual Review of Pharmacology and Toxicology

SN - 0362-1642

ER -