The genome of yoka poxvirus

Guoyan Zhao, Lindsay Droit, Robert B. Tesh, Vsevolod Popov, Nicole S. Little, Chris Upton, Herbert W. Virgin, David Wang

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Yoka poxvirus was isolated almost four decades ago from a mosquito pool in the Central African Republic. Its classification as a poxvirus is based solely upon the morphology of virions visualized by electron microscopy. Here we describe sequencing of the Yoka poxvirus genome using a combination of Roche/454 and Illumina next-generation sequencing technologies. A single consensus contig of ~175 kb in length that encodes 186 predicted genes was generated. Multiple methods were used to show that Yoka poxvirus is most closely related to viruses in the Orthopoxvirus genus, but it is clearly distinct from previously described poxviruses. Collectively, the phylogenetic and genomic sequence analyses suggest that Yoka poxvirus is the prototype member of a new genus in the family Poxviridae.

Original languageEnglish (US)
Pages (from-to)10230-10238
Number of pages9
JournalJournal of Virology
Volume85
Issue number19
DOIs
StatePublished - Oct 2011

Fingerprint

Poxviridae
Genome
genome
Central African Republic
Orthopoxvirus
Culicidae
virion
prototypes
Virion
Sequence Analysis
new genus
electron microscopy
Electron Microscopy
Viruses
Technology
taxonomy
genomics
viruses
phylogeny

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Zhao, G., Droit, L., Tesh, R. B., Popov, V., Little, N. S., Upton, C., ... Wang, D. (2011). The genome of yoka poxvirus. Journal of Virology, 85(19), 10230-10238. https://doi.org/10.1128/JVI.00637-11

The genome of yoka poxvirus. / Zhao, Guoyan; Droit, Lindsay; Tesh, Robert B.; Popov, Vsevolod; Little, Nicole S.; Upton, Chris; Virgin, Herbert W.; Wang, David.

In: Journal of Virology, Vol. 85, No. 19, 10.2011, p. 10230-10238.

Research output: Contribution to journalArticle

Zhao, G, Droit, L, Tesh, RB, Popov, V, Little, NS, Upton, C, Virgin, HW & Wang, D 2011, 'The genome of yoka poxvirus', Journal of Virology, vol. 85, no. 19, pp. 10230-10238. https://doi.org/10.1128/JVI.00637-11
Zhao G, Droit L, Tesh RB, Popov V, Little NS, Upton C et al. The genome of yoka poxvirus. Journal of Virology. 2011 Oct;85(19):10230-10238. https://doi.org/10.1128/JVI.00637-11
Zhao, Guoyan ; Droit, Lindsay ; Tesh, Robert B. ; Popov, Vsevolod ; Little, Nicole S. ; Upton, Chris ; Virgin, Herbert W. ; Wang, David. / The genome of yoka poxvirus. In: Journal of Virology. 2011 ; Vol. 85, No. 19. pp. 10230-10238.
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