The GP-protein of Marburg virus contains the region similar to the 'immunosuppressive domain' of oncogenic retrovirus P15E proteins

A. A. Bukreyev; V. E. Volchkov; V. M. Blinov; S. V. Netesov

doi:10.1016/0014-5793(93)81476-G

The GP-protein of Marburg virus contains the region similar to the 'immunosuppressive domain' of oncogenic retrovirus P15E proteins

A. A. Bukreyev, V. E. Volchkov, V. M. Blinov, S. V. Netesov

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

cDNA was synthesized and cloned on the template of the genomic RNA of Marburg virus (strain Popp). Recombinant plasmids with specific cDNA inserts were selected and sequenced. The length of the open reading frame encoding the GP-protein is 681 amino acids. GP-protein is proposed to be an integral membrane protein. Computer-assisted comparison of the deduced amino acid sequence with those of different viruses revealed significant homology with the GP-protein of Ebola virus and with the 'immunosuppressive domain" of the P15E envelope proteins of some oncogenic retroviruses.

Original language	English (US)
Pages (from-to)	183-187
Number of pages	5
Journal	FEBS Letters
Volume	323
Issue number	1-2
DOIs	https://doi.org/10.1016/0014-5793(93)81476-G
State	Published - May 24 1993
Externally published	Yes

Keywords

Envelope protein
Filoviridae
Immunosuppressive domain
Marburg virus
cDNA

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

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10.1016/0014-5793(93)81476-G

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title = "The GP-protein of Marburg virus contains the region similar to the 'immunosuppressive domain' of oncogenic retrovirus P15E proteins",

abstract = "cDNA was synthesized and cloned on the template of the genomic RNA of Marburg virus (strain Popp). Recombinant plasmids with specific cDNA inserts were selected and sequenced. The length of the open reading frame encoding the GP-protein is 681 amino acids. GP-protein is proposed to be an integral membrane protein. Computer-assisted comparison of the deduced amino acid sequence with those of different viruses revealed significant homology with the GP-protein of Ebola virus and with the 'immunosuppressive domain{"} of the P15E envelope proteins of some oncogenic retroviruses.",

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T1 - The GP-protein of Marburg virus contains the region similar to the 'immunosuppressive domain' of oncogenic retrovirus P15E proteins

AU - Bukreyev, A. A.

AU - Volchkov, V. E.

AU - Blinov, V. M.

AU - Netesov, S. V.

PY - 1993/5/24

Y1 - 1993/5/24

N2 - cDNA was synthesized and cloned on the template of the genomic RNA of Marburg virus (strain Popp). Recombinant plasmids with specific cDNA inserts were selected and sequenced. The length of the open reading frame encoding the GP-protein is 681 amino acids. GP-protein is proposed to be an integral membrane protein. Computer-assisted comparison of the deduced amino acid sequence with those of different viruses revealed significant homology with the GP-protein of Ebola virus and with the 'immunosuppressive domain" of the P15E envelope proteins of some oncogenic retroviruses.

AB - cDNA was synthesized and cloned on the template of the genomic RNA of Marburg virus (strain Popp). Recombinant plasmids with specific cDNA inserts were selected and sequenced. The length of the open reading frame encoding the GP-protein is 681 amino acids. GP-protein is proposed to be an integral membrane protein. Computer-assisted comparison of the deduced amino acid sequence with those of different viruses revealed significant homology with the GP-protein of Ebola virus and with the 'immunosuppressive domain" of the P15E envelope proteins of some oncogenic retroviruses.

KW - Envelope protein

KW - Filoviridae

KW - Immunosuppressive domain

KW - Marburg virus

KW - cDNA

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The GP-protein of Marburg virus contains the region similar to the 'immunosuppressive domain' of oncogenic retrovirus P15E proteins

Abstract

Keywords

ASJC Scopus subject areas

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