The hepatic response to thermal injury

Marc G. Jeschke, Omar Nunez Lopez, Celeste C. Finnerty

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

A severe burn injury induces a hypermetabolic response that negatively impacts glucose homeostasis, fat metabolism, and protein balance. The liver plays a pivotal role mediating the disarrangements observed in glycogenolysis, glycolysis, gluconeogenesis, lipolysis, and proteolysis, all of which are part of this systemic response. Clinical observations and investigative studies have helped us to understand the function of the liver in the pathophysiology of severe burn injuries including the association between preserved hepatic function and favorable outcomes. This chapter summarizes the key concepts, underlying biologic mechanisms, and the latest advances addressing the post-burn role of the liver.

Original languageEnglish (US)
Title of host publicationTotal Burn Care
Subtitle of host publicationFifth Edition
PublisherElsevier Inc.
Pages259-267.e3
ISBN (Electronic)9780323497428
ISBN (Print)9780323476614
DOIs
StatePublished - Jan 1 2018

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Keywords

  • Acute phase reactants
  • Burn injury
  • Burns
  • Cytokines
  • Hepatic response
  • Hypermetabolic response
  • Inflammation
  • Liver
  • Thermal injury

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Jeschke, M. G., Lopez, O. N., & Finnerty, C. C. (2018). The hepatic response to thermal injury. In Total Burn Care: Fifth Edition (pp. 259-267.e3). Elsevier Inc.. https://doi.org/10.1016/B978-0-323-47661-4.00024-1