The Hurler and Hunter syndromes

Albert Dorfman; Reuben Matalon

doi:10.1016/0002-9343(69)90164-8

The Hurler and Hunter syndromes

Albert Dorfman, Reuben Matalon

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Since the demonstration that acid mucopolysaccharides accumulate in tissue and urines of patients with the Hurler and Hunter syndromes, other mucopolysaccharidoses have been described. Some lipid storage diseases have also been shown to have an increase in acid mucopolysaccharide with the lipid material stored. Tissue culture technics have shed some light on several aspects of these diseases especially with regard to genetic counselling. Available information is reviewed in an attempt to reconcile current knowledge in arriving at a unifying hypothesis.

Original language	English (US)
Pages (from-to)	691-707
Number of pages	17
Journal	The American Journal of Medicine
Volume	47
Issue number	5
DOIs	https://doi.org/10.1016/0002-9343(69)90164-8
State	Published - Nov 1969
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1016/0002-9343(69)90164-8

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title = "The Hurler and Hunter syndromes",

abstract = "Since the demonstration that acid mucopolysaccharides accumulate in tissue and urines of patients with the Hurler and Hunter syndromes, other mucopolysaccharidoses have been described. Some lipid storage diseases have also been shown to have an increase in acid mucopolysaccharide with the lipid material stored. Tissue culture technics have shed some light on several aspects of these diseases especially with regard to genetic counselling. Available information is reviewed in an attempt to reconcile current knowledge in arriving at a unifying hypothesis.",

author = "Albert Dorfman and Reuben Matalon",

note = "Funding Information: * Fro111 the Departments of Pediatrics and Biochemistry, LaRabida-University of Chicago Institute, and the ~trsc~ph I{\textquoteright}. Kennedy. Jr. Mental Retardation Research Center, University of Chicago, Chicago, Illinois 60637. {\textquoteleft}This \~ork IY~S suppol.tcd by grants from U. S. Public Health Service (AM-05996 and FR 00305), the Illinois and Cllicago lIeart Associations and the Cystic Fibrosis Foundation. Requests for reprints should be adtll-es& to lh .\llxw Dorfman, Department of Pediatrics, University of Chicago, 950 East 59th Street, Chicago, Illinois 60637. i Joseph P. Kennedy, Jr. Scholar.",

year = "1969",

month = nov,

doi = "10.1016/0002-9343(69)90164-8",

language = "English (US)",

volume = "47",

pages = "691--707",

journal = "The American Journal of Medicine",

issn = "0002-9343",

publisher = "Elsevier Inc.",

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AU - Dorfman, Albert

AU - Matalon, Reuben

N1 - Funding Information: * Fro111 the Departments of Pediatrics and Biochemistry, LaRabida-University of Chicago Institute, and the ~trsc~ph I’. Kennedy. Jr. Mental Retardation Research Center, University of Chicago, Chicago, Illinois 60637. ‘This \~ork IY~S suppol.tcd by grants from U. S. Public Health Service (AM-05996 and FR 00305), the Illinois and Cllicago lIeart Associations and the Cystic Fibrosis Foundation. Requests for reprints should be adtll-es& to lh .\llxw Dorfman, Department of Pediatrics, University of Chicago, 950 East 59th Street, Chicago, Illinois 60637. i Joseph P. Kennedy, Jr. Scholar.

PY - 1969/11

Y1 - 1969/11

N2 - Since the demonstration that acid mucopolysaccharides accumulate in tissue and urines of patients with the Hurler and Hunter syndromes, other mucopolysaccharidoses have been described. Some lipid storage diseases have also been shown to have an increase in acid mucopolysaccharide with the lipid material stored. Tissue culture technics have shed some light on several aspects of these diseases especially with regard to genetic counselling. Available information is reviewed in an attempt to reconcile current knowledge in arriving at a unifying hypothesis.

AB - Since the demonstration that acid mucopolysaccharides accumulate in tissue and urines of patients with the Hurler and Hunter syndromes, other mucopolysaccharidoses have been described. Some lipid storage diseases have also been shown to have an increase in acid mucopolysaccharide with the lipid material stored. Tissue culture technics have shed some light on several aspects of these diseases especially with regard to genetic counselling. Available information is reviewed in an attempt to reconcile current knowledge in arriving at a unifying hypothesis.

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JO - The American Journal of Medicine

JF - The American Journal of Medicine

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ER -

The Hurler and Hunter syndromes

Abstract

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