The Hypermetabolic Response to Burn Injury and Interventions to Modify this Response

Felicia N. Williams, David Herndon, Marc G. Jeschke

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Severe burn injury is followed by a profound hypermetabolic response that persists up to 24 months after injury. It is mediated by up to 50-fold elevations in plasma catecholamines, cortisol, and inflammatory cells that lead to whole-body catabolism, elevated resting energy expenditures, and multiorgan dysfunction. All of these metabolic and physiologic derangements prevent full rehabilitation and acclimatization of burn survivors back into society. Modulation of the response by early excision and grafting of burn wounds, thermoregulation, early and continuous enteral feeding with high-protein high-carbohydrate feedings, and pharmacologic treatments have markedly decreased morbidity.

Original languageEnglish (US)
Pages (from-to)583-596
Number of pages14
JournalClinics in Plastic Surgery
Volume36
Issue number4
DOIs
StatePublished - Oct 2009

Fingerprint

Wounds and Injuries
Body Temperature Regulation
Acclimatization
Enteral Nutrition
Energy Metabolism
Catecholamines
Survivors
Hydrocortisone
Rehabilitation
Carbohydrates
Morbidity
Proteins
Therapeutics

Keywords

  • β-blockade
  • Burns
  • Catabolism
  • Catecholamines
  • Hypermetabolism
  • Wasting

ASJC Scopus subject areas

  • Surgery

Cite this

The Hypermetabolic Response to Burn Injury and Interventions to Modify this Response. / Williams, Felicia N.; Herndon, David; Jeschke, Marc G.

In: Clinics in Plastic Surgery, Vol. 36, No. 4, 10.2009, p. 583-596.

Research output: Contribution to journalArticle

Williams, Felicia N. ; Herndon, David ; Jeschke, Marc G. / The Hypermetabolic Response to Burn Injury and Interventions to Modify this Response. In: Clinics in Plastic Surgery. 2009 ; Vol. 36, No. 4. pp. 583-596.
@article{df88a7bbca8447898f12eb78663c56d5,
title = "The Hypermetabolic Response to Burn Injury and Interventions to Modify this Response",
abstract = "Severe burn injury is followed by a profound hypermetabolic response that persists up to 24 months after injury. It is mediated by up to 50-fold elevations in plasma catecholamines, cortisol, and inflammatory cells that lead to whole-body catabolism, elevated resting energy expenditures, and multiorgan dysfunction. All of these metabolic and physiologic derangements prevent full rehabilitation and acclimatization of burn survivors back into society. Modulation of the response by early excision and grafting of burn wounds, thermoregulation, early and continuous enteral feeding with high-protein high-carbohydrate feedings, and pharmacologic treatments have markedly decreased morbidity.",
keywords = "β-blockade, Burns, Catabolism, Catecholamines, Hypermetabolism, Wasting",
author = "Williams, {Felicia N.} and David Herndon and Jeschke, {Marc G.}",
year = "2009",
month = "10",
doi = "10.1016/j.cps.2009.05.001",
language = "English (US)",
volume = "36",
pages = "583--596",
journal = "Clinics in Plastic Surgery",
issn = "0094-1298",
publisher = "W.B. Saunders Ltd",
number = "4",

}

TY - JOUR

T1 - The Hypermetabolic Response to Burn Injury and Interventions to Modify this Response

AU - Williams, Felicia N.

AU - Herndon, David

AU - Jeschke, Marc G.

PY - 2009/10

Y1 - 2009/10

N2 - Severe burn injury is followed by a profound hypermetabolic response that persists up to 24 months after injury. It is mediated by up to 50-fold elevations in plasma catecholamines, cortisol, and inflammatory cells that lead to whole-body catabolism, elevated resting energy expenditures, and multiorgan dysfunction. All of these metabolic and physiologic derangements prevent full rehabilitation and acclimatization of burn survivors back into society. Modulation of the response by early excision and grafting of burn wounds, thermoregulation, early and continuous enteral feeding with high-protein high-carbohydrate feedings, and pharmacologic treatments have markedly decreased morbidity.

AB - Severe burn injury is followed by a profound hypermetabolic response that persists up to 24 months after injury. It is mediated by up to 50-fold elevations in plasma catecholamines, cortisol, and inflammatory cells that lead to whole-body catabolism, elevated resting energy expenditures, and multiorgan dysfunction. All of these metabolic and physiologic derangements prevent full rehabilitation and acclimatization of burn survivors back into society. Modulation of the response by early excision and grafting of burn wounds, thermoregulation, early and continuous enteral feeding with high-protein high-carbohydrate feedings, and pharmacologic treatments have markedly decreased morbidity.

KW - β-blockade

KW - Burns

KW - Catabolism

KW - Catecholamines

KW - Hypermetabolism

KW - Wasting

UR - http://www.scopus.com/inward/record.url?scp=70349314619&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70349314619&partnerID=8YFLogxK

U2 - 10.1016/j.cps.2009.05.001

DO - 10.1016/j.cps.2009.05.001

M3 - Article

C2 - 19793553

AN - SCOPUS:70349314619

VL - 36

SP - 583

EP - 596

JO - Clinics in Plastic Surgery

JF - Clinics in Plastic Surgery

SN - 0094-1298

IS - 4

ER -