The Hypermetabolic Response to Burn Injury and Interventions to Modify this Response

Felicia N. Williams, David N. Herndon, Marc G. Jeschke

Research output: Contribution to journalReview article

92 Scopus citations

Abstract

Severe burn injury is followed by a profound hypermetabolic response that persists up to 24 months after injury. It is mediated by up to 50-fold elevations in plasma catecholamines, cortisol, and inflammatory cells that lead to whole-body catabolism, elevated resting energy expenditures, and multiorgan dysfunction. All of these metabolic and physiologic derangements prevent full rehabilitation and acclimatization of burn survivors back into society. Modulation of the response by early excision and grafting of burn wounds, thermoregulation, early and continuous enteral feeding with high-protein high-carbohydrate feedings, and pharmacologic treatments have markedly decreased morbidity.

Original languageEnglish (US)
Pages (from-to)583-596
Number of pages14
JournalClinics in Plastic Surgery
Volume36
Issue number4
DOIs
StatePublished - Oct 2009

Keywords

  • Burns
  • Catabolism
  • Catecholamines
  • Hypermetabolism
  • Wasting
  • β-blockade

ASJC Scopus subject areas

  • Surgery

Fingerprint Dive into the research topics of 'The Hypermetabolic Response to Burn Injury and Interventions to Modify this Response'. Together they form a unique fingerprint.

  • Cite this