Abstract
The present study identifies a pair of inhibitory cells that are located on each anterolateral margin of a leech segmental ganglion. These cells, termed 119 cells, are electrically interconnected. They give rise to inhibitory junctional potentials (ijp's) in contralateral longitudinal body wall muscle cells. The latencies of the ijp's following spikes in cell 119 are variable. The ijp's are caused by transient increases in permeability to the Cl- ion. Previous studies demonstrated that 5 HT causes a hyperpolarization of body wall muscle cells by increasing the permeability of muscle membrane to the Cl- ion. Accordingly, 5 HT was searched for in the 119 cell bodies, but autoradiography, fine structure, and gas chromatography mass spectrometry gave no indication that 5 HT was present in these cells. However, the variable latencies of the ijp's may indicate that there is a neuron interposed between cell 119 and the muscle cells. If this is the case, then the interposed neuron should be analyzed for 5 HT. Further experiments to locate the terminals of cells 119 and the cell bodies of the presumed interposed neurons are thus desirable.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 435-445 |
| Number of pages | 11 |
| Journal | Journal of Neurobiology |
| Volume | 7 |
| Issue number | 5 |
| State | Published - 1976 |
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ASJC Scopus subject areas
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The identification of two inhibitory cells in each segmental ganglion of the leech and studies on the ionic mechanism of the inhibitory junctional potentials produced by these cells. / Sawada, M.; Wilkinson, J. M.; McAdoo, D. J.; Coggeshall, R. E.
In: Journal of Neurobiology, Vol. 7, No. 5, 1976, p. 435-445.Research output: Contribution to journal › Article
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TY - JOUR
T1 - The identification of two inhibitory cells in each segmental ganglion of the leech and studies on the ionic mechanism of the inhibitory junctional potentials produced by these cells
AU - Sawada, M.
AU - Wilkinson, J. M.
AU - McAdoo, D. J.
AU - Coggeshall, R. E.
PY - 1976
Y1 - 1976
N2 - The present study identifies a pair of inhibitory cells that are located on each anterolateral margin of a leech segmental ganglion. These cells, termed 119 cells, are electrically interconnected. They give rise to inhibitory junctional potentials (ijp's) in contralateral longitudinal body wall muscle cells. The latencies of the ijp's following spikes in cell 119 are variable. The ijp's are caused by transient increases in permeability to the Cl- ion. Previous studies demonstrated that 5 HT causes a hyperpolarization of body wall muscle cells by increasing the permeability of muscle membrane to the Cl- ion. Accordingly, 5 HT was searched for in the 119 cell bodies, but autoradiography, fine structure, and gas chromatography mass spectrometry gave no indication that 5 HT was present in these cells. However, the variable latencies of the ijp's may indicate that there is a neuron interposed between cell 119 and the muscle cells. If this is the case, then the interposed neuron should be analyzed for 5 HT. Further experiments to locate the terminals of cells 119 and the cell bodies of the presumed interposed neurons are thus desirable.
AB - The present study identifies a pair of inhibitory cells that are located on each anterolateral margin of a leech segmental ganglion. These cells, termed 119 cells, are electrically interconnected. They give rise to inhibitory junctional potentials (ijp's) in contralateral longitudinal body wall muscle cells. The latencies of the ijp's following spikes in cell 119 are variable. The ijp's are caused by transient increases in permeability to the Cl- ion. Previous studies demonstrated that 5 HT causes a hyperpolarization of body wall muscle cells by increasing the permeability of muscle membrane to the Cl- ion. Accordingly, 5 HT was searched for in the 119 cell bodies, but autoradiography, fine structure, and gas chromatography mass spectrometry gave no indication that 5 HT was present in these cells. However, the variable latencies of the ijp's may indicate that there is a neuron interposed between cell 119 and the muscle cells. If this is the case, then the interposed neuron should be analyzed for 5 HT. Further experiments to locate the terminals of cells 119 and the cell bodies of the presumed interposed neurons are thus desirable.
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UR - http://www.scopus.com/inward/citedby.url?scp=0017190814&partnerID=8YFLogxK
M3 - Article
C2 - 185332
AN - SCOPUS:0017190814
VL - 7
SP - 435
EP - 445
JO - Developmental Neurobiology
JF - Developmental Neurobiology
SN - 1932-8451
IS - 5
ER -