The immunomodulating v and W proteins of Nipah virus determine disease course

Benjamin A. Satterfield, Robert Cross, Karla A. Fenton, Krystle N. Agans, Christopher F. Basler, Thomas Geisbert, Chad Mire

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

The viral determinants that contribute to Nipah virus (NiV)-mediated disease are poorly understood compared with other paramyxoviruses. Here we use recombinant NiVs (rNiVs) to examine the contributions of the NiV V and W proteins to NiV pathogenesis in a ferret model. We show that a V-deficient rNiV is susceptible to the innate immune response in vitro and behaves as a replicating non-lethal virus in vivo. Remarkably, rNiV lacking W expression results in a delayed and altered disease course with decreased respiratory disease and increased terminal neurological disease associated with altered in vitro inflammatory cytokine production. This study confirms the V protein as the major determinant of pathogenesis, also being the first in vivo study to show that the W protein modulates the inflammatory host immune response in a manner that determines the disease course.

Original languageEnglish (US)
Article number7483
JournalNature Communications
Volume6
DOIs
StatePublished - Jun 24 2015

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry(all)
  • Physics and Astronomy(all)

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