The Impact of MRSA Colonization on Surgical Site Infection Following Major Gastrointestinal Surgery

Marcela C. Ramirez, Michelle Marchessault, Cara Govednik-Horny, Daniel Jupiter, Harry T. Papaconstantinou

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Purpose: The purpose of this study is to determine whether methicillin-resistant Staphylococcus aureus (MRSA) colonization affects surgical site infections (SSI) after major gastrointestinal (GI) operations. Methods: We retrospectively reviewed the charts of all patients undergoing major GI surgery from December 2007 to August 2009. All patients were tested for MRSA colonization and grouped according to results (MRSA+, methicillin-sensitive S. aureus [MSSA]+, and negative). Data analyzed included demographics, incidence of SSI, and wound culture results. Results: A total of 1,137 patients were identified; 78. 9 % negative, 14. 7 % MSSA+, and 6. 4 % MRSA+. The mean age was 59. 5 years, 44. 5 % of the patients were men, and 47. 9 % of the patients underwent colorectal operation. SSI was identified in 101 (8. 9 %) patients and was higher in the MRSA+ group than the negative and MSSA+ groups (13. 7 vs. 9. 4 vs. 4. 2 %; p < 0. 05). Although MRSA colonization had an odds ratio of 1. 43 for developing an SSI, it was not a significant independent risk factor. However, the MRSA+ group was strongly associated with MRSA cultured from the wound when SSI was present (70 vs. 8. 5 %; p < 0. 0001). Conclusions: MRSA colonization is not an independent risk factor for SSI following major GI operations; however, it is strongly predictive of MRSA-associated SSI in these patients. Preoperative MRSA nasal swab test with decolonization may reduce the incidence of MRSA-associated SSI after major GI surgery.

Original languageEnglish (US)
Pages (from-to)144-152
Number of pages9
JournalJournal of Gastrointestinal Surgery
Volume17
Issue number1
DOIs
StatePublished - 2013
Externally publishedYes

Fingerprint

Surgical Wound Infection
Methicillin-Resistant Staphylococcus aureus
Methicillin
Staphylococcus aureus
Incidence
Wounds and Injuries
Nose

Keywords

  • Gastrointestinal surgery
  • MRSA colonization
  • Surgical site infection

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

Cite this

The Impact of MRSA Colonization on Surgical Site Infection Following Major Gastrointestinal Surgery. / Ramirez, Marcela C.; Marchessault, Michelle; Govednik-Horny, Cara; Jupiter, Daniel; Papaconstantinou, Harry T.

In: Journal of Gastrointestinal Surgery, Vol. 17, No. 1, 2013, p. 144-152.

Research output: Contribution to journalArticle

Ramirez, Marcela C. ; Marchessault, Michelle ; Govednik-Horny, Cara ; Jupiter, Daniel ; Papaconstantinou, Harry T. / The Impact of MRSA Colonization on Surgical Site Infection Following Major Gastrointestinal Surgery. In: Journal of Gastrointestinal Surgery. 2013 ; Vol. 17, No. 1. pp. 144-152.
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