The impact of obesity on neurodegenerative diseases

Janaína Niero Mazon, Aline Haas de Mello, Gabriela Kozuchovski Ferreira, Gislaine Tezza Rezin

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

Neurodegenerative diseases are a growing health concern. The increasing incidences of these disorders have a great impact on the patients' quality of life. Although the mechanisms of neurodegenerative diseases are still far from being clarified, several studies look for new discoveries about their pathophysiology and prevention. Furthermore, evidence has shown a strong correlation between obesity and the development of Alzheimer's disease (AD) and Parkinson's disease (PD). Metabolic changes caused by overweight are related to damage to the central nervous system (CNS), which can lead to neural death, either by apoptosis or cell necrosis, as well as alter the synaptic plasticity of the neuron. This review aims to show the association between neurodegenerative diseases, focusing on AD and PD, and metabolic alterations.

Original languageEnglish (US)
Pages (from-to)22-28
Number of pages7
JournalLife Sciences
Volume182
DOIs
StatePublished - Aug 1 2017
Externally publishedYes

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Keywords

  • Alzheimer's disease
  • Neurodegenerative diseases
  • Obesity
  • Parkinson's disease

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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