TY - JOUR
T1 - The impact of obesity-related neuroinflammation on postpartum depression
T2 - A narrative review
AU - da Cruz, Kenia Lourdes de Oliveira
AU - Salla, Daniele Hendler
AU - de Oliveira, Mariana Pacheco
AU - da Silva, Larissa Espindola
AU - Dela Vedova, Larissa Marques
AU - Mendes, Talita Farias
AU - Bressan, Catarina Barbosa Chaves
AU - Costa, Ana Beatriz
AU - da Silva, Mariella Reinol
AU - Réus, Gislaine Zilli
AU - de Mello, Aline Haas
AU - Rezin, Gislaine Tezza
N1 - Publisher Copyright:
© 2022 International Society for Developmental Neuroscience.
PY - 2022/8
Y1 - 2022/8
N2 - Obesity is currently one of the most serious health problems, affecting 13% of the world's adult population. Obesity is characterized by persistent low-grade chronic inflammation that assumes systemic proportions and triggers several associated metabolic diseases. Furthermore, obesity has been associated with an increased occurrence of central disorders such as impaired cognitive function, reward system dysfunction, and depression. In summary, there is a quantitative reduction in the release of neurotransmitters in depression. Postsynaptic cells capture lower concentrations of neurotransmitters, which leads to a functional reduction in the central nervous system (CNS). Globally, approximately 15–65% of women experience depressive symptoms during pregnancy, depending on their location. Depressive symptoms persist in some women, leading to postpartum depression (PPD). Thus, obesity may be considered a risk factor for PPD development. This study aimed to synthesize studies on the impact of obesity-related neuroinflammation and PPD. We conducted a narrative review of the relevant literature. The search was performed in electronic databases, specifically PubMed, selecting articles in English published from 2014 to 2021 using the narrative review methodology.
AB - Obesity is currently one of the most serious health problems, affecting 13% of the world's adult population. Obesity is characterized by persistent low-grade chronic inflammation that assumes systemic proportions and triggers several associated metabolic diseases. Furthermore, obesity has been associated with an increased occurrence of central disorders such as impaired cognitive function, reward system dysfunction, and depression. In summary, there is a quantitative reduction in the release of neurotransmitters in depression. Postsynaptic cells capture lower concentrations of neurotransmitters, which leads to a functional reduction in the central nervous system (CNS). Globally, approximately 15–65% of women experience depressive symptoms during pregnancy, depending on their location. Depressive symptoms persist in some women, leading to postpartum depression (PPD). Thus, obesity may be considered a risk factor for PPD development. This study aimed to synthesize studies on the impact of obesity-related neuroinflammation and PPD. We conducted a narrative review of the relevant literature. The search was performed in electronic databases, specifically PubMed, selecting articles in English published from 2014 to 2021 using the narrative review methodology.
KW - depression
KW - neuroinflammation
KW - obesity
KW - postpartum depression
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U2 - 10.1002/jdn.10198
DO - 10.1002/jdn.10198
M3 - Review article
C2 - 35595536
AN - SCOPUS:85132585677
SN - 0736-5748
VL - 82
SP - 375
EP - 384
JO - International Journal of Developmental Neuroscience
JF - International Journal of Developmental Neuroscience
IS - 5
ER -