The impact of obesity-related neuroinflammation on postpartum depression: A narrative review

Kenia Lourdes de Oliveira da Cruz, Daniele Hendler Salla, Mariana Pacheco de Oliveira, Larissa Espindola da Silva, Larissa Marques Dela Vedova, Talita Farias Mendes, Catarina Barbosa Chaves Bressan, Ana Beatriz Costa, Mariella Reinol da Silva, Gislaine Zilli Réus, Aline Haas de Mello, Gislaine Tezza Rezin

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations


Obesity is currently one of the most serious health problems, affecting 13% of the world's adult population. Obesity is characterized by persistent low-grade chronic inflammation that assumes systemic proportions and triggers several associated metabolic diseases. Furthermore, obesity has been associated with an increased occurrence of central disorders such as impaired cognitive function, reward system dysfunction, and depression. In summary, there is a quantitative reduction in the release of neurotransmitters in depression. Postsynaptic cells capture lower concentrations of neurotransmitters, which leads to a functional reduction in the central nervous system (CNS). Globally, approximately 15–65% of women experience depressive symptoms during pregnancy, depending on their location. Depressive symptoms persist in some women, leading to postpartum depression (PPD). Thus, obesity may be considered a risk factor for PPD development. This study aimed to synthesize studies on the impact of obesity-related neuroinflammation and PPD. We conducted a narrative review of the relevant literature. The search was performed in electronic databases, specifically PubMed, selecting articles in English published from 2014 to 2021 using the narrative review methodology.

Original languageEnglish (US)
Pages (from-to)375-384
Number of pages10
JournalInternational Journal of Developmental Neuroscience
Issue number5
StatePublished - Aug 2022
Externally publishedYes


  • depression
  • neuroinflammation
  • obesity
  • postpartum depression

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology


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