The impact of severe burns on skeletal muscle mitochondrial function

Craig Porter, David Herndon, Labros S. Sidossis, Elisabet Børsheim

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Severe burns induce a pathophysiological response that affects almost every physiological system within the body. Inflammation, hypermetabolism, muscle wasting, and insulin resistance are all hallmarks of the pathophysiological response to severe burns, with perturbations in metabolism known to persist for several years post injury. Skeletal muscle is the principal depot of lean tissue within the body and as the primary site of peripheral glucose disposal, plays an important role in metabolic regulation. Following a large burn, skeletal muscle functions as and endogenous amino acid store, providing substrates for more pressing functions, such as the synthesis of acute phase proteins and the deposition of new skin. Subsequently, burn patients become cachectic, which is associated with poor outcomes in terms of metabolic health and functional capacity. While a loss of skeletal muscle contractile proteins per se will no doubt negatively impact functional capacity, detriments in skeletal muscle quality, i.e. a loss in mitochondrial number and/or function may be quantitatively just as important. The goal of this review article is to summarise the current understanding of the impact of thermal trauma on skeletal muscle mitochondrial content and function, to offer direction for future research concerning skeletal muscle mitochondrial function in patients with severe burns, and to renew interest in the role of these organelles in metabolic dysfunction following severe burns.

Original languageEnglish (US)
Pages (from-to)1039-1047
Number of pages9
JournalBurns
Volume39
Issue number6
DOIs
StatePublished - Sep 2013

Fingerprint

Burns
Skeletal Muscle
Contractile Proteins
Acute-Phase Proteins
Muscle Proteins
Wounds and Injuries
Organelles
Insulin Resistance
Hot Temperature
Inflammation
Amino Acids
Glucose
Muscles
Skin
Health

Keywords

  • Burn
  • Mitochondrial function
  • Skeletal muscle

ASJC Scopus subject areas

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine
  • Surgery

Cite this

Porter, C., Herndon, D., Sidossis, L. S., & Børsheim, E. (2013). The impact of severe burns on skeletal muscle mitochondrial function. Burns, 39(6), 1039-1047. https://doi.org/10.1016/j.burns.2013.03.018

The impact of severe burns on skeletal muscle mitochondrial function. / Porter, Craig; Herndon, David; Sidossis, Labros S.; Børsheim, Elisabet.

In: Burns, Vol. 39, No. 6, 09.2013, p. 1039-1047.

Research output: Contribution to journalArticle

Porter, C, Herndon, D, Sidossis, LS & Børsheim, E 2013, 'The impact of severe burns on skeletal muscle mitochondrial function', Burns, vol. 39, no. 6, pp. 1039-1047. https://doi.org/10.1016/j.burns.2013.03.018
Porter, Craig ; Herndon, David ; Sidossis, Labros S. ; Børsheim, Elisabet. / The impact of severe burns on skeletal muscle mitochondrial function. In: Burns. 2013 ; Vol. 39, No. 6. pp. 1039-1047.
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