The importance of intestinal glutamine metabolism in maintaining a healthy gastrointestinal tract and supporting the body's response to injury and illness.

Vicki Klimberg, W. W. Souba

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

In critically ill surgical patients, a variety of therapeutic maneuvers are required to maintain a healthy GI tract. Provision of adequate amounts of glutamine to the gastrointestinal mucosa appears to be just one of these maneuvers. Other methods used to protect the GI tract from becoming a wound are (1) to avoid additional systemic and local insults (such as hypotension, sepsis, and multiple operative procedures); (2) to provide aggressive pulmonary care; (3) to use antibiotics judiciously; and (4) to provide aggressive enteral or parenteral feedings. The concept that the intestine is an organ of quiescence after surgical stress merits reconsideration. The intestinal tract plays a central role in interorgan glutamine metabolism and is a key regulator of nitrogen handling after surgical stress. Critically ill patients are susceptible to sepsis of GI origin, the incidence of which is diminished by instituting measures that support intestinal structure, function, and metabolism. Clearly, the biochemical and functional importance of the GI tract in surgical stress demands further elucidation of these factors.

Original languageEnglish (US)
Pages (from-to)61-76
Number of pages16
JournalSurgery annual
Volume22
StatePublished - 1990
Externally publishedYes

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Glutamine
Gastrointestinal Tract
Critical Illness
Sepsis
Wounds and Injuries
Parenteral Nutrition
Operative Surgical Procedures
Enteral Nutrition
Hypotension
Intestines
Mucous Membrane
Nitrogen
Anti-Bacterial Agents
Lung
Incidence
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "The importance of intestinal glutamine metabolism in maintaining a healthy gastrointestinal tract and supporting the body's response to injury and illness.",
abstract = "In critically ill surgical patients, a variety of therapeutic maneuvers are required to maintain a healthy GI tract. Provision of adequate amounts of glutamine to the gastrointestinal mucosa appears to be just one of these maneuvers. Other methods used to protect the GI tract from becoming a wound are (1) to avoid additional systemic and local insults (such as hypotension, sepsis, and multiple operative procedures); (2) to provide aggressive pulmonary care; (3) to use antibiotics judiciously; and (4) to provide aggressive enteral or parenteral feedings. The concept that the intestine is an organ of quiescence after surgical stress merits reconsideration. The intestinal tract plays a central role in interorgan glutamine metabolism and is a key regulator of nitrogen handling after surgical stress. Critically ill patients are susceptible to sepsis of GI origin, the incidence of which is diminished by instituting measures that support intestinal structure, function, and metabolism. Clearly, the biochemical and functional importance of the GI tract in surgical stress demands further elucidation of these factors.",
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N2 - In critically ill surgical patients, a variety of therapeutic maneuvers are required to maintain a healthy GI tract. Provision of adequate amounts of glutamine to the gastrointestinal mucosa appears to be just one of these maneuvers. Other methods used to protect the GI tract from becoming a wound are (1) to avoid additional systemic and local insults (such as hypotension, sepsis, and multiple operative procedures); (2) to provide aggressive pulmonary care; (3) to use antibiotics judiciously; and (4) to provide aggressive enteral or parenteral feedings. The concept that the intestine is an organ of quiescence after surgical stress merits reconsideration. The intestinal tract plays a central role in interorgan glutamine metabolism and is a key regulator of nitrogen handling after surgical stress. Critically ill patients are susceptible to sepsis of GI origin, the incidence of which is diminished by instituting measures that support intestinal structure, function, and metabolism. Clearly, the biochemical and functional importance of the GI tract in surgical stress demands further elucidation of these factors.

AB - In critically ill surgical patients, a variety of therapeutic maneuvers are required to maintain a healthy GI tract. Provision of adequate amounts of glutamine to the gastrointestinal mucosa appears to be just one of these maneuvers. Other methods used to protect the GI tract from becoming a wound are (1) to avoid additional systemic and local insults (such as hypotension, sepsis, and multiple operative procedures); (2) to provide aggressive pulmonary care; (3) to use antibiotics judiciously; and (4) to provide aggressive enteral or parenteral feedings. The concept that the intestine is an organ of quiescence after surgical stress merits reconsideration. The intestinal tract plays a central role in interorgan glutamine metabolism and is a key regulator of nitrogen handling after surgical stress. Critically ill patients are susceptible to sepsis of GI origin, the incidence of which is diminished by instituting measures that support intestinal structure, function, and metabolism. Clearly, the biochemical and functional importance of the GI tract in surgical stress demands further elucidation of these factors.

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