The importance of total number of sentinel lymph nodes in patients with stage NO cutaneous melanoma

Laura E. Stewart, Douglas S. Tyler, Robin T. Vollmer

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Staging of malignant melanoma now relies routinely on the sentinel node (SN) technique. On average, 2.1 SNs are removed per patient. Nevertheless, despite the success of the SN technique, approximately 10% of patients with negative SNs experience metastatic recurrence. Because a prior theoretical analysis using Poisson and Bayes probability models suggested that limited sampling of SNs could cause false-negative results, we undertook this study to see whether the subset of patients with negative SNs and only 1 or 2 nodes examined have a shorter time to recurrence than patients with 3 or more nodes examined and found to be negative. Our study cases comprised 178 melanoma cases with SN biopsy: positive SN, 47; negative SN and fewer than 3 nodes examined, 68; and negative SN and more than 2 nodes examined, 63. Patients with negative SNs and fewer than 3 examined had disease-free survival intermediate between patients with positive SNs and those with negative SNs and more than 2 examined (P = .013). These results suggest that among patients with negative SNs, those with fewer than 3 nodes examined have greater risk for recurrence.

Original languageEnglish (US)
Pages (from-to)77-82
Number of pages6
JournalAmerican journal of clinical pathology
Issue number1
StatePublished - Jul 2005
Externally publishedYes


  • Melanoma
  • Metastasis
  • Probability
  • Sentinel node
  • Tumor recurrence

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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