The In Vivo Antiviral Effect of CL246,738 is Mediated by the Independent Induction of Interferon-α and Interferon-β

M. Sarzotti, D. H. Coppenhaver, I. P. Singh, J. Poast, S. Baron

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

An interferon (IFN) inducer and immunomodulator, CL246,738 [3,6-bis(2-piperidinoethoxy)acridine trihydrochloride], protected mice from lethal infection with Semliki Forest (SFV) and Banzi (BZV) viruses. A single oral dose of CL246,738 (5–150 mg/kg) administered 24 h before intraperitoneal challenge with SFV or BZV fully protected mice from lethal infection. Dose-dependent levels of circulating IFN peaked at 24 h in the serum and peritoneal fluid of CL246,738-treated mice. The circulating IFN of CL246,738-treated mice consisted of IFN-α and was produced by spleen cells. Peritoneal exudate cells (PEC) obtained from CL246,738-treated mice produced IFN-β. Treatment in vivo with anti-IFN-α/β and anti-IFN-β reversed the protective effect of CL246,738 against lethal SFV encephalitis.

Original languageEnglish (US)
Pages (from-to)265-274
Number of pages10
JournalJournal of Interferon Research
Volume9
Issue number3
DOIs
StatePublished - Jun 1989

ASJC Scopus subject areas

  • Immunology
  • Virology

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