The in vivo antiviral effect of CL246,738 is mediated by the independent induction of interferon-α and interferon-β

M. Sarzotti, D. H. Coppenhaver, I. P. Singh, J. Poast, S. Baron

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

An interferon (IFN) inducer and immunomodulator, CL246,738 [3,6-bis(2-piperidinoethoxy)acridine trihydrochloride], protected mice from lethal infection with Semliki Forest (SFV) and Banzi (BZV) viruses. A single oral dose of CL246,738 (5-150 mg/kg) administered 24 h before intraperitoneal challenge with SFV or BZV fully protected mice from lethal infection. Dose-dependent levels of circulating IFN peaked at 24 h in the serum and peritoneal fluid of CL246,738-treated mice. The circulating IFN of CL246,738-treated mice consisted of IFN-α and was produced by spleen cells. Peritoneal exudate cells (PEC) obtained from CL246,738-treated mice produced IFN-β. Treatment in vivo with anti-IFN-α/β and anti-IFN-β reversed the protective effect of CL246,738 against lethal SFV encephalitis.

Original languageEnglish (US)
Pages (from-to)265-274
Number of pages10
JournalJournal of Interferon Research
Volume9
Issue number3
StatePublished - 1989

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Interferons
Antiviral Agents
Interferon Inducers
Ascitic Fluid
Immunologic Factors
Exudates and Transudates
Encephalitis
Infection
Spleen
Viruses
Serum

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Sarzotti, M., Coppenhaver, D. H., Singh, I. P., Poast, J., & Baron, S. (1989). The in vivo antiviral effect of CL246,738 is mediated by the independent induction of interferon-α and interferon-β. Journal of Interferon Research, 9(3), 265-274.

The in vivo antiviral effect of CL246,738 is mediated by the independent induction of interferon-α and interferon-β. / Sarzotti, M.; Coppenhaver, D. H.; Singh, I. P.; Poast, J.; Baron, S.

In: Journal of Interferon Research, Vol. 9, No. 3, 1989, p. 265-274.

Research output: Contribution to journalArticle

Sarzotti, M, Coppenhaver, DH, Singh, IP, Poast, J & Baron, S 1989, 'The in vivo antiviral effect of CL246,738 is mediated by the independent induction of interferon-α and interferon-β', Journal of Interferon Research, vol. 9, no. 3, pp. 265-274.
Sarzotti, M. ; Coppenhaver, D. H. ; Singh, I. P. ; Poast, J. ; Baron, S. / The in vivo antiviral effect of CL246,738 is mediated by the independent induction of interferon-α and interferon-β. In: Journal of Interferon Research. 1989 ; Vol. 9, No. 3. pp. 265-274.
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