The increased expression of CD21 on AchR specified B cells in patients with myasthenia gravis

Weifan Yin; Windy Allman; Song Ouyang; Yi Li; Jing Li; Premkumar Christadoss; Huan Yang

doi:10.1016/j.jneuroim.2012.11.003

The increased expression of CD21 on AchR specified B cells in patients with myasthenia gravis

Weifan Yin
, Windy Allman
, Song Ouyang
, Yi Li
, Jing Li
, Premkumar Christadoss
, Huan Yang

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

CD21, a major complement receptor expressed on B cells, is associated with autoimmune disorders. In the present study, we investigated the role of CD21 in pathogenesis of myasthenia gravis (MG) in relationship to anti-acetylcholine receptor (AchR) IgG (anti-AchR IgG) secretion. We detected increased surface expression of CD21 on AchR specified B cells as well as decreased surface expression of CD21 on total B cells in peripheral blood of patients with generalized MG (gMG). In addition, the serum concentrations of soluble secreted CD21 (sCD21) were decreased in patients with gMG. We also found that the level of CD21⁺ AchR specified B cells correlated positively with serum anti-AchR IgG level, while the serum concentration of soluble CD21 correlated negatively with serum anti-AchR IgG level. Our data suggests that CD21 might facilitate its function on AchR specified B cell activation, resulting in the secretion of anti-AchR IgG.

Original language	English (US)
Pages (from-to)	49-54
Number of pages	6
Journal	Journal of Neuroimmunology
Volume	256
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2012.11.003
State	Published - Mar 15 2013
Externally published	Yes

Keywords

Acetylcholine receptor (AchR)
Autoimmunity
B cells
CD21
Myasthenia gravis (MG)
Pathogenesis

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2012.11.003

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@article{b34efa5a0ff04e2c852075a19ba51a59,

title = "The increased expression of CD21 on AchR specified B cells in patients with myasthenia gravis",

abstract = "CD21, a major complement receptor expressed on B cells, is associated with autoimmune disorders. In the present study, we investigated the role of CD21 in pathogenesis of myasthenia gravis (MG) in relationship to anti-acetylcholine receptor (AchR) IgG (anti-AchR IgG) secretion. We detected increased surface expression of CD21 on AchR specified B cells as well as decreased surface expression of CD21 on total B cells in peripheral blood of patients with generalized MG (gMG). In addition, the serum concentrations of soluble secreted CD21 (sCD21) were decreased in patients with gMG. We also found that the level of CD21+ AchR specified B cells correlated positively with serum anti-AchR IgG level, while the serum concentration of soluble CD21 correlated negatively with serum anti-AchR IgG level. Our data suggests that CD21 might facilitate its function on AchR specified B cell activation, resulting in the secretion of anti-AchR IgG.",

keywords = "Acetylcholine receptor (AchR), Autoimmunity, B cells, CD21, Myasthenia gravis (MG), Pathogenesis",

author = "Weifan Yin and Windy Allman and Song Ouyang and Yi Li and Jing Li and Premkumar Christadoss and Huan Yang",

note = "Funding Information: This work was supported by the National Nature Science Foundation of China (No. 81070962 ), MDA , and innovation project for postgraduate of central south university (No. 2010ssxt058).",

year = "2013",

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doi = "10.1016/j.jneuroim.2012.11.003",

language = "English (US)",

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AU - Yin, Weifan

AU - Allman, Windy

AU - Ouyang, Song

AU - Li, Yi

AU - Li, Jing

AU - Christadoss, Premkumar

AU - Yang, Huan

N1 - Funding Information: This work was supported by the National Nature Science Foundation of China (No. 81070962 ), MDA , and innovation project for postgraduate of central south university (No. 2010ssxt058).

PY - 2013/3/15

Y1 - 2013/3/15

N2 - CD21, a major complement receptor expressed on B cells, is associated with autoimmune disorders. In the present study, we investigated the role of CD21 in pathogenesis of myasthenia gravis (MG) in relationship to anti-acetylcholine receptor (AchR) IgG (anti-AchR IgG) secretion. We detected increased surface expression of CD21 on AchR specified B cells as well as decreased surface expression of CD21 on total B cells in peripheral blood of patients with generalized MG (gMG). In addition, the serum concentrations of soluble secreted CD21 (sCD21) were decreased in patients with gMG. We also found that the level of CD21+ AchR specified B cells correlated positively with serum anti-AchR IgG level, while the serum concentration of soluble CD21 correlated negatively with serum anti-AchR IgG level. Our data suggests that CD21 might facilitate its function on AchR specified B cell activation, resulting in the secretion of anti-AchR IgG.

AB - CD21, a major complement receptor expressed on B cells, is associated with autoimmune disorders. In the present study, we investigated the role of CD21 in pathogenesis of myasthenia gravis (MG) in relationship to anti-acetylcholine receptor (AchR) IgG (anti-AchR IgG) secretion. We detected increased surface expression of CD21 on AchR specified B cells as well as decreased surface expression of CD21 on total B cells in peripheral blood of patients with generalized MG (gMG). In addition, the serum concentrations of soluble secreted CD21 (sCD21) were decreased in patients with gMG. We also found that the level of CD21+ AchR specified B cells correlated positively with serum anti-AchR IgG level, while the serum concentration of soluble CD21 correlated negatively with serum anti-AchR IgG level. Our data suggests that CD21 might facilitate its function on AchR specified B cell activation, resulting in the secretion of anti-AchR IgG.

KW - Acetylcholine receptor (AchR)

KW - Autoimmunity

KW - B cells

KW - CD21

KW - Myasthenia gravis (MG)

KW - Pathogenesis

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U2 - 10.1016/j.jneuroim.2012.11.003

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The increased expression of CD21 on AchR specified B cells in patients with myasthenia gravis

Abstract

Keywords

ASJC Scopus subject areas

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