The induction of interferon by levamisole in mice

Shuzo Matsubara, Fujio Suzuki, Nakao Ishida

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Viral inhibitor(s) with the properties of interferon (IF) was found in the sera of DDI mice injected intraperitoneally with 5 to 10 mg/kg of levamisole. A significant level of IF activity appeared by 20 hr and reached a peak by 24 hr after the injection. The induction was abrogated when the mice were pretreated with either whole-body X irradiation of more than 500 R or 2.5 mg of hydrocortisone acetate but was not affected by macrophage-specific depressors such as carrageenan and trypan blue. Also, no induction was detected in thymus-defective nude mice. These results suggest that thymus-derived lymphocytes in the mouse may be required for IF induction by levamisole.

Original languageEnglish (US)
Pages (from-to)214-219
Number of pages6
JournalCellular Immunology
Issue number1
StatePublished - Mar 1 1979
Externally publishedYes

ASJC Scopus subject areas

  • Immunology


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