Abstract
Viral inhibitor(s) with the properties of interferon (IF) was found in the sera of DDI mice injected intraperitoneally with 5 to 10 mg/kg of levamisole. A significant level of IF activity appeared by 20 hr and reached a peak by 24 hr after the injection. The induction was abrogated when the mice were pretreated with either whole-body X irradiation of more than 500 R or 2.5 mg of hydrocortisone acetate but was not affected by macrophage-specific depressors such as carrageenan and trypan blue. Also, no induction was detected in thymus-defective nude mice. These results suggest that thymus-derived lymphocytes in the mouse may be required for IF induction by levamisole.
Original language | English (US) |
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Pages (from-to) | 214-219 |
Number of pages | 6 |
Journal | Cellular Immunology |
Volume | 43 |
Issue number | 1 |
DOIs | |
State | Published - Mar 1 1979 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology