TY - JOUR
T1 - The Infected Lungs and Brain Interface in COVID-19
T2 - The Impact on Cognitive Function
AU - Joaquim, Larissa
AU - Della Giustina, Amanda
AU - Machado, Richard Simon
AU - Metzker, Kiuanne Lino Lobo
AU - Bonfante, Sandra
AU - Danielski, Lucineia Gainski
AU - De Souza Goldim, Mariana Pereira
AU - Petronilho, Fabricia
N1 - Publisher Copyright:
Copyright © 2022 S. Karger AG, Basel. All rights reserved.
PY - 2022/12/1
Y1 - 2022/12/1
N2 - Many coronavirus disease 2019 (COVID-19)-recovered patients report signs and symptoms and are experiencing neurological, psychiatric, and cognitive problems. However, the exact prevalence and outcome of cognitive sequelae is unclear. Even though the severe acute respiratory syndrome coronavirus 2 has target brain cells through binding to angiotensin-converting enzyme 2 (ACE2) receptor in acute infection, several studies indicate the absence of the virus in the brain of many COVID-19 patients who developed neurological disorders. Thus, the COVID-19 mechanisms for stimulating cognitive dysfunction may include neuroinflammation, which is mediated by a sustained systemic inflammation, a disrupted brain barrier, and severe glial reactiveness, especially within the limbic system. This review explores the interplay of infected lungs and brain in COVID-19 and its impact on the cognitive function.
AB - Many coronavirus disease 2019 (COVID-19)-recovered patients report signs and symptoms and are experiencing neurological, psychiatric, and cognitive problems. However, the exact prevalence and outcome of cognitive sequelae is unclear. Even though the severe acute respiratory syndrome coronavirus 2 has target brain cells through binding to angiotensin-converting enzyme 2 (ACE2) receptor in acute infection, several studies indicate the absence of the virus in the brain of many COVID-19 patients who developed neurological disorders. Thus, the COVID-19 mechanisms for stimulating cognitive dysfunction may include neuroinflammation, which is mediated by a sustained systemic inflammation, a disrupted brain barrier, and severe glial reactiveness, especially within the limbic system. This review explores the interplay of infected lungs and brain in COVID-19 and its impact on the cognitive function.
KW - Cognitive dysfunction
KW - COVID-19
KW - Neuroinflammation
KW - SARS-CoV-2
UR - http://www.scopus.com/inward/record.url?scp=85144244364&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85144244364&partnerID=8YFLogxK
U2 - 10.1159/000526653
DO - 10.1159/000526653
M3 - Review article
C2 - 36323239
AN - SCOPUS:85144244364
SN - 1021-7401
VL - 29
SP - 269
EP - 281
JO - NeuroImmunoModulation
JF - NeuroImmunoModulation
IS - 4
ER -