The influence of ΔfosB in the nucleus accumbens on natural reward-related behavior

Deanna L. Wallace, Vincent Vialou, Loretta Rios, Tiffany L. Carle-Florence, Sumana Chakravarty, Arvind Kumar, Danielle L. Graham, Thomas Green, Anne Kirk, Sergio D. Iñiguez, Linda I. Perrotti, Michel Barrot, Ralph J. DiLeone, Eric J. Nestler, Carlos A. Bolaños-Guzmán

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

The transcription factor deltaFosB (ΔFosB), induced in nucleus accumbens (NAc) by chronic exposure to drugs of abuse, has been shown to mediate sensitized responses to these drugs. However, less is known about a role for ΔFosB in regulating responses to natural rewards. Here, we demonstrate that two powerful natural reward behaviors, sucrose drinking and sexual behavior, increase levels of ΔFosB in the NAc. We then use viral-mediated gene transfer to study how such ΔFosB induction influences behavioral responses to these natural rewards. We demonstrate that overexpression of ΔFosB in the NAc increases sucrose intake and promotes aspects of sexual behavior. In addition, we show that animals with previous sexual experience, which exhibit increased ΔFosB levels, also show an increase in sucrose consumption. This work suggests that ΔFosB is not only induced in the NAc by drugs of abuse, but also by natural rewarding stimuli. Additionally, our findings show that chronic exposure to stimuli that induce ΔFosB in the NAc can increase consumption of other natural rewards.

Original languageEnglish (US)
Pages (from-to)10272-10277
Number of pages6
JournalJournal of Neuroscience
Volume28
Issue number41
DOIs
StatePublished - Oct 8 2008
Externally publishedYes

Fingerprint

Nucleus Accumbens
Reward
Sucrose
Street Drugs
Sexual Behavior
Drinking Behavior
Viral Genes
Transcription Factors
Pharmaceutical Preparations

Keywords

  • Behavior
  • Nucleus accumbens
  • Obesity
  • Reward
  • Sex
  • Sucrose
  • Transcription factor

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

Wallace, D. L., Vialou, V., Rios, L., Carle-Florence, T. L., Chakravarty, S., Kumar, A., ... Bolaños-Guzmán, C. A. (2008). The influence of ΔfosB in the nucleus accumbens on natural reward-related behavior. Journal of Neuroscience, 28(41), 10272-10277. https://doi.org/10.1523/JNEUROSCI.1531-08.2008

The influence of ΔfosB in the nucleus accumbens on natural reward-related behavior. / Wallace, Deanna L.; Vialou, Vincent; Rios, Loretta; Carle-Florence, Tiffany L.; Chakravarty, Sumana; Kumar, Arvind; Graham, Danielle L.; Green, Thomas; Kirk, Anne; Iñiguez, Sergio D.; Perrotti, Linda I.; Barrot, Michel; DiLeone, Ralph J.; Nestler, Eric J.; Bolaños-Guzmán, Carlos A.

In: Journal of Neuroscience, Vol. 28, No. 41, 08.10.2008, p. 10272-10277.

Research output: Contribution to journalArticle

Wallace, DL, Vialou, V, Rios, L, Carle-Florence, TL, Chakravarty, S, Kumar, A, Graham, DL, Green, T, Kirk, A, Iñiguez, SD, Perrotti, LI, Barrot, M, DiLeone, RJ, Nestler, EJ & Bolaños-Guzmán, CA 2008, 'The influence of ΔfosB in the nucleus accumbens on natural reward-related behavior', Journal of Neuroscience, vol. 28, no. 41, pp. 10272-10277. https://doi.org/10.1523/JNEUROSCI.1531-08.2008
Wallace DL, Vialou V, Rios L, Carle-Florence TL, Chakravarty S, Kumar A et al. The influence of ΔfosB in the nucleus accumbens on natural reward-related behavior. Journal of Neuroscience. 2008 Oct 8;28(41):10272-10277. https://doi.org/10.1523/JNEUROSCI.1531-08.2008
Wallace, Deanna L. ; Vialou, Vincent ; Rios, Loretta ; Carle-Florence, Tiffany L. ; Chakravarty, Sumana ; Kumar, Arvind ; Graham, Danielle L. ; Green, Thomas ; Kirk, Anne ; Iñiguez, Sergio D. ; Perrotti, Linda I. ; Barrot, Michel ; DiLeone, Ralph J. ; Nestler, Eric J. ; Bolaños-Guzmán, Carlos A. / The influence of ΔfosB in the nucleus accumbens on natural reward-related behavior. In: Journal of Neuroscience. 2008 ; Vol. 28, No. 41. pp. 10272-10277.
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