The influence of carbon dioxide and body position on near-infrared spectroscopic assessment of cerebral hemoglobin oxygen saturation

Valerie Pollard, Donald Prough, A. Eric DeMelo, Donald J. Deyo, Tatsuo Uchida, Ron Widman

Research output: Contribution to journalArticle

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Abstract

Near-infrared spectroscopy may allow continuous and noninvasive monitoring of regional brain hemoglobin oxygen saturation by measuring the differential absorption of infrared light by oxyhemoglobin and deoxyhemoglobin. We have previously examined the correlation between the spectroscopic signal generated by a prototype cerebral oximeter (Invos 3100®; Somanetics, Troy, MI), and global brain hemoglobin oxygen saturation calculated from arterial and jugular venous bulb oxygen saturations. Because the technology does not distinguish between arterial and venous hemoglobin saturation, changes in the proportion of cerebral arterial and venous blood volume, which may result from changes in blood flow or venous distending pressure, may confound measurements. In eight conscious volunteers breathing hypoxic oxygen mixtures, we examined the influence of supine, 20° Trendeleburg, and 20° reverse Trendelenburg positions on the correlation of the spectroscopic measurement of cerebral oxygen saturation in the field assessed by the probe (CS(f)O 2) and the calculated brain hemoglobin oxygen saturation (CS(comb)O 2), estimated as 0.25 x arterial saturation plus 0.75 x jugular venous bulb oxygen saturation. We found that changes in position did not influence the association between CS(f)O 2 and CS(comb)O 2 (r 2 =0.69-0.885) during hypoxic challenge. In a second set of eight volunteers, we studied the influence of hypercapnia and hypocapnia and body position on the association between CS(f)O 2 and CS(comb)O 2, and found that they were less well correlated (r 2 = 0.366-0.976) in individual patients. Because changes in body position and PaCO 2 confound the relationship between CS(f)O 2 and CS(comb)O 2, changes in CS(f)O 2 can best be assessed if position and PaCO 2 are constant.

Original languageEnglish (US)
Pages (from-to)278-287
Number of pages10
JournalAnesthesia and Analgesia
Volume82
Issue number2
DOIs
StatePublished - 1996

Fingerprint

Carbon Dioxide
Hemoglobins
Comb and Wattles
Oxygen
Volunteers
Brain
Neck
Head-Down Tilt
Hypocapnia
Oxyhemoglobins
Venous Pressure
Near-Infrared Spectroscopy
Hypercapnia
Blood Volume
Respiration
Technology
Light

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

The influence of carbon dioxide and body position on near-infrared spectroscopic assessment of cerebral hemoglobin oxygen saturation. / Pollard, Valerie; Prough, Donald; Eric DeMelo, A.; Deyo, Donald J.; Uchida, Tatsuo; Widman, Ron.

In: Anesthesia and Analgesia, Vol. 82, No. 2, 1996, p. 278-287.

Research output: Contribution to journalArticle

Pollard, Valerie ; Prough, Donald ; Eric DeMelo, A. ; Deyo, Donald J. ; Uchida, Tatsuo ; Widman, Ron. / The influence of carbon dioxide and body position on near-infrared spectroscopic assessment of cerebral hemoglobin oxygen saturation. In: Anesthesia and Analgesia. 1996 ; Vol. 82, No. 2. pp. 278-287.
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