The influence of meal frequency and timing on health in humans

The role of fasting

Antonio Paoli, Grant Tinsley, Antonino Bianco, Tatiana Moro

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

The influence of meal frequency and timing on health and disease has been a topic of interest for many years. While epidemiological evidence indicates an association between higher meal frequencies and lower disease risk, experimental trials have shown conflicting results. Furthermore, recent prospective research has demonstrated a significant increase in disease risk with a high meal frequency (≥6 meals/day) as compared to a low meal frequency (1-2 meals/day). Apart from meal frequency and timing we also have to consider breakfast consumption and the distribution of daily energy intake, caloric restriction, and night-time eating. A central role in this complex scenario is played by the fasting period length between two meals. The physiological underpinning of these interconnected variables may be through internal circadian clocks, and food consumption that is asynchronous with natural circadian rhythms may exert adverse health effects and increase disease risk. Additionally, alterations in meal frequency and meal timing have the potential to influence energy and macronutrient intake.A regular meal pattern including breakfast consumption, consuming a higher proportion of energy early in the day, reduced meal frequency (i.e., 2-3 meals/day), and regular fasting periods may provide physiological benefits such as reduced inflammation, improved circadian rhythmicity, increased autophagy and stress resistance, and modulation of the gut microbiota.

Original languageEnglish (US)
Article number719
JournalNutrients
Volume11
Issue number4
DOIs
StatePublished - Apr 1 2019

Fingerprint

meals (menu)
fasting
Meals
human health
Fasting
Health
Breakfast
breakfast
Energy Intake
circadian rhythm
Caloric Restriction
Circadian Clocks
autophagy
Autophagy
energy
Periodicity
Circadian Rhythm
intestinal microorganisms
stress tolerance
food consumption

Keywords

  • Cardiovascular health
  • Diabetes
  • Fasting
  • Meal frequency
  • Meal timing
  • Obesity
  • Time-restricted feeding

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

Cite this

The influence of meal frequency and timing on health in humans : The role of fasting. / Paoli, Antonio; Tinsley, Grant; Bianco, Antonino; Moro, Tatiana.

In: Nutrients, Vol. 11, No. 4, 719, 01.04.2019.

Research output: Contribution to journalReview article

Paoli, Antonio ; Tinsley, Grant ; Bianco, Antonino ; Moro, Tatiana. / The influence of meal frequency and timing on health in humans : The role of fasting. In: Nutrients. 2019 ; Vol. 11, No. 4.
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