The influence of simple aromatics on benzene clastogenicity

Barbara L. Harper, V-M Ramanujam, Mohy M. Gad-El-Karim, Marvin S. Legator

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The micronucleus test was performed in male ICR Swiss mice following modification of benzene metabolism by co-administration of aniline, pyridine or napythalene, or by prior injection of α-naphthoflavone. HPLC profiles of urinary metabolites were compared to the effects of these compounds on clastogenicity. Pyridine inhibited both benzene clastogenicity and its metabolism. Aniline and naphthalene increase the clastogenicity and slightly altered the metabolism of benzene. α-Naphthoflavone inhibited benzene increase the metabolism of benzene but noly 3-methylcholanthrene increases benzene clastogenicity, specific P450 isozymes may be responsible for different biological effects benzene, and alterations in these effects might be caused by a shift from the isozyme to another.

Original languageEnglish (US)
Pages (from-to)105-114
Number of pages10
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume128
Issue number2
DOIs
StatePublished - 1984

Fingerprint

Benzene
Isoenzymes
Inbred ICR Mouse
Micronucleus Tests
Methylcholanthrene
High Pressure Liquid Chromatography
Injections

ASJC Scopus subject areas

  • Molecular Biology
  • Health, Toxicology and Mutagenesis
  • Medicine(all)

Cite this

The influence of simple aromatics on benzene clastogenicity. / Harper, Barbara L.; Ramanujam, V-M; Gad-El-Karim, Mohy M.; Legator, Marvin S.

In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 128, No. 2, 1984, p. 105-114.

Research output: Contribution to journalArticle

Harper, Barbara L. ; Ramanujam, V-M ; Gad-El-Karim, Mohy M. ; Legator, Marvin S. / The influence of simple aromatics on benzene clastogenicity. In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 1984 ; Vol. 128, No. 2. pp. 105-114.
@article{99260311078346fd984b9e638a7a4063,
title = "The influence of simple aromatics on benzene clastogenicity",
abstract = "The micronucleus test was performed in male ICR Swiss mice following modification of benzene metabolism by co-administration of aniline, pyridine or napythalene, or by prior injection of α-naphthoflavone. HPLC profiles of urinary metabolites were compared to the effects of these compounds on clastogenicity. Pyridine inhibited both benzene clastogenicity and its metabolism. Aniline and naphthalene increase the clastogenicity and slightly altered the metabolism of benzene. α-Naphthoflavone inhibited benzene increase the metabolism of benzene but noly 3-methylcholanthrene increases benzene clastogenicity, specific P450 isozymes may be responsible for different biological effects benzene, and alterations in these effects might be caused by a shift from the isozyme to another.",
author = "Harper, {Barbara L.} and V-M Ramanujam and Gad-El-Karim, {Mohy M.} and Legator, {Marvin S.}",
year = "1984",
doi = "10.1016/0027-5107(84)90097-6",
language = "English (US)",
volume = "128",
pages = "105--114",
journal = "Mutation Research",
issn = "0027-5107",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - The influence of simple aromatics on benzene clastogenicity

AU - Harper, Barbara L.

AU - Ramanujam, V-M

AU - Gad-El-Karim, Mohy M.

AU - Legator, Marvin S.

PY - 1984

Y1 - 1984

N2 - The micronucleus test was performed in male ICR Swiss mice following modification of benzene metabolism by co-administration of aniline, pyridine or napythalene, or by prior injection of α-naphthoflavone. HPLC profiles of urinary metabolites were compared to the effects of these compounds on clastogenicity. Pyridine inhibited both benzene clastogenicity and its metabolism. Aniline and naphthalene increase the clastogenicity and slightly altered the metabolism of benzene. α-Naphthoflavone inhibited benzene increase the metabolism of benzene but noly 3-methylcholanthrene increases benzene clastogenicity, specific P450 isozymes may be responsible for different biological effects benzene, and alterations in these effects might be caused by a shift from the isozyme to another.

AB - The micronucleus test was performed in male ICR Swiss mice following modification of benzene metabolism by co-administration of aniline, pyridine or napythalene, or by prior injection of α-naphthoflavone. HPLC profiles of urinary metabolites were compared to the effects of these compounds on clastogenicity. Pyridine inhibited both benzene clastogenicity and its metabolism. Aniline and naphthalene increase the clastogenicity and slightly altered the metabolism of benzene. α-Naphthoflavone inhibited benzene increase the metabolism of benzene but noly 3-methylcholanthrene increases benzene clastogenicity, specific P450 isozymes may be responsible for different biological effects benzene, and alterations in these effects might be caused by a shift from the isozyme to another.

UR - http://www.scopus.com/inward/record.url?scp=0021194747&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021194747&partnerID=8YFLogxK

U2 - 10.1016/0027-5107(84)90097-6

DO - 10.1016/0027-5107(84)90097-6

M3 - Article

VL - 128

SP - 105

EP - 114

JO - Mutation Research

JF - Mutation Research

SN - 0027-5107

IS - 2

ER -