The influence of the vaginal microbiota on preterm birth

A systematic review and recommendations for a minimum dataset for future research

PREBIC Biomarker Working Group 2014–2018

Research output: Contribution to journalReview article

Abstract

Objective: This systematic review aims to identify, critically appraise and summarize the results of studies examining the relationship between the vaginal microbiota and preterm birth (PTB). Methods: We searched the electronic databases Medline, EMBASE and the Cochrane Controlled Register of Trials for studies in any language reporting on vaginal microbiota and PTB published from 1990 to November 29th, 2017. We included any study that performed lower genital tract microbiota assessment in asymptomatic pregnant women and reported on spontaneous preterm birth, with either intact or ruptured membranes. Results: The search strategy yielded 2171 unique citations, of which nine studies were eligible for inclusion in this review. In six studies an association was found between the composition of the vaginal microbiota and PTB, but findings differed between subgroups, ethnicities and degree of risk of PTB. In three studies no association was found. Two of these studies found a significant difference in richness and Shannon diversity between term and PTB. Conclusions: We have demonstrated that there is a paucity of molecular based, culture-independent studies that analyse the relationship between the vaginal microbiota and PTB as an outcome. The heterogeneity precluded a meta-analysis. Studies provide contradictory evidence and the quality of the clinical information in the studies is poor. To improve quality of future studies we have provided a database of essential and desirable items of quality that are method and topic specific.

Original languageEnglish (US)
JournalPlacenta
DOIs
StatePublished - Jan 1 2019

Fingerprint

Microbiota
Premature Birth
Databases
Term Birth
Datasets
Meta-Analysis
Pregnant Women
Language
Membranes

Keywords

  • Bacterial vaginosis
  • Cultivation-independent
  • Lactobacillus iners
  • Molecular-based and community-state-types
  • Polymerase chain reaction
  • Preterm Birth
  • Systematic review
  • Vaginal dysbiosis
  • Vaginal microbiome
  • Vaginal microbiota

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Developmental Biology

Cite this

The influence of the vaginal microbiota on preterm birth : A systematic review and recommendations for a minimum dataset for future research. / PREBIC Biomarker Working Group 2014–2018.

In: Placenta, 01.01.2019.

Research output: Contribution to journalReview article

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abstract = "Objective: This systematic review aims to identify, critically appraise and summarize the results of studies examining the relationship between the vaginal microbiota and preterm birth (PTB). Methods: We searched the electronic databases Medline, EMBASE and the Cochrane Controlled Register of Trials for studies in any language reporting on vaginal microbiota and PTB published from 1990 to November 29th, 2017. We included any study that performed lower genital tract microbiota assessment in asymptomatic pregnant women and reported on spontaneous preterm birth, with either intact or ruptured membranes. Results: The search strategy yielded 2171 unique citations, of which nine studies were eligible for inclusion in this review. In six studies an association was found between the composition of the vaginal microbiota and PTB, but findings differed between subgroups, ethnicities and degree of risk of PTB. In three studies no association was found. Two of these studies found a significant difference in richness and Shannon diversity between term and PTB. Conclusions: We have demonstrated that there is a paucity of molecular based, culture-independent studies that analyse the relationship between the vaginal microbiota and PTB as an outcome. The heterogeneity precluded a meta-analysis. Studies provide contradictory evidence and the quality of the clinical information in the studies is poor. To improve quality of future studies we have provided a database of essential and desirable items of quality that are method and topic specific.",
keywords = "Bacterial vaginosis, Cultivation-independent, Lactobacillus iners, Molecular-based and community-state-types, Polymerase chain reaction, Preterm Birth, Systematic review, Vaginal dysbiosis, Vaginal microbiome, Vaginal microbiota",
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AU - PREBIC Biomarker Working Group 2014–2018

AU - Peelen, Myrthe JCS

AU - Luef, Birgitte Møller

AU - Lamont, Ronald F.

AU - de Milliano, Inge

AU - Jensen, Jørgen Skov

AU - Limpens, Jacqueline

AU - Hajenius, Petra J.

AU - Jørgensen, Jan Stener

AU - Menon, Ramkumar

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AB - Objective: This systematic review aims to identify, critically appraise and summarize the results of studies examining the relationship between the vaginal microbiota and preterm birth (PTB). Methods: We searched the electronic databases Medline, EMBASE and the Cochrane Controlled Register of Trials for studies in any language reporting on vaginal microbiota and PTB published from 1990 to November 29th, 2017. We included any study that performed lower genital tract microbiota assessment in asymptomatic pregnant women and reported on spontaneous preterm birth, with either intact or ruptured membranes. Results: The search strategy yielded 2171 unique citations, of which nine studies were eligible for inclusion in this review. In six studies an association was found between the composition of the vaginal microbiota and PTB, but findings differed between subgroups, ethnicities and degree of risk of PTB. In three studies no association was found. Two of these studies found a significant difference in richness and Shannon diversity between term and PTB. Conclusions: We have demonstrated that there is a paucity of molecular based, culture-independent studies that analyse the relationship between the vaginal microbiota and PTB as an outcome. The heterogeneity precluded a meta-analysis. Studies provide contradictory evidence and the quality of the clinical information in the studies is poor. To improve quality of future studies we have provided a database of essential and desirable items of quality that are method and topic specific.

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KW - Vaginal dysbiosis

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