The intolerable burden of Chikungunya

What's new, what's needed?

Shailendra K. Saxena, M. L. Arvinda Swamy, Sunil K. Verma, Rakhi Saxena

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Chikungunya virus (CHIKV) is an emerging arthropod born virus belonging to genus Alphavirus and family Togaviridae with a ?(ve) sense single stranded RNA of 11.8 Kb as genome. CHIKV infections are not new, its presence was felt in the early nineteenth century but it was confined mostly to few regions in Africa and Asia. The recent outbreak which erupted in Asia and many European countries was due to combinatorial effect of various factors like climatic changes, due to global warming, that helped the vector population. Mutations in the viral genome, mostly E1 gene played a major role in the adaptation of the virus to mosquitoes, causing epidemics. Human behavioral factors like travel from endemic to non endemic regions, lack of proper sanitation and awareness on arthropod borne diseases resulted in the massive CHIKV epidemics all over the world. Especially in India, various reports came from many states but the worst affected states being Andhra Pradesh, Tamilnadu, Maharashtra, Karnataka and Kerala. CHIKV is not a fatal disease but some deaths have been reported in different parts of the globe. CHIKV not only affected the human health, but also had a heavy impact on the individual and national economy. CHIKV vaccines studies are raising hope for the effective treatment against the CHIKV infection. Till then the population and further growth of vectors for Chikungunya (Aedes aegypti and Aedes albopictus mosquitoes) can be controlled by proper sanitation practices and public awareness on the arthropod borne diseases.

Original languageEnglish (US)
Pages (from-to)153-165
Number of pages13
JournalProceedings of the National Academy of Sciences India Section B - Biological Sciences
Volume82
Issue number1 MAJOR HUMAN VIRAL
DOIs
StatePublished - Jan 2012
Externally publishedYes

Fingerprint

Chikungunya virus
virus
Sanitation
Arthropods
India
Aedes
arthropod-borne diseases
Culicidae
Togaviridae
arthropod
sanitation
Alphavirus
Global Warming
Arboviruses
Viral Genome
Population Growth
mosquito
viruses
Disease Outbreaks
genome

Keywords

  • Aedes aegypti
  • Aedes albopictus
  • Chikungunya
  • CHIKV
  • Epidemic
  • Mosquitoes
  • Vector
  • Virus

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Environmental Science(all)

Cite this

The intolerable burden of Chikungunya : What's new, what's needed? / Saxena, Shailendra K.; Arvinda Swamy, M. L.; Verma, Sunil K.; Saxena, Rakhi.

In: Proceedings of the National Academy of Sciences India Section B - Biological Sciences, Vol. 82, No. 1 MAJOR HUMAN VIRAL, 01.2012, p. 153-165.

Research output: Contribution to journalArticle

Saxena, Shailendra K. ; Arvinda Swamy, M. L. ; Verma, Sunil K. ; Saxena, Rakhi. / The intolerable burden of Chikungunya : What's new, what's needed?. In: Proceedings of the National Academy of Sciences India Section B - Biological Sciences. 2012 ; Vol. 82, No. 1 MAJOR HUMAN VIRAL. pp. 153-165.
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