The intravenous furosemide test: a simple way to evaluate renin responsiveness

N. M. Kaplan, D. C. Kem, O. B. Holland, N. J. Kramer, J. Higgins, C. Gomez-Sanchez

Research output: Contribution to journalArticlepeer-review

124 Scopus citations


To identify patients with low renin hypertension, the authors measured plasma renin activity after the administration of 40 mg of furosemide intravenously and 30 minutes of upright posture in 127 normotensive subjects and 363 patients with essential hypertension. Plasma renin activity 30 minutes after intravenous furosemide was found to be closely correlated to the level found after either 2 or 4 h of standing or 3 days of a low salt diet plus 2 h of upright posture. Renin responsiveness was significantly lower in hypertensive patients, blacks, and women, compared with normotensive subjects, whites, and men respectively. The level of plasma renin activity in most normal white subjects was greater than 1.0 ng/ml/h and in most normal blacks was greater than 0.5 ng/ml/h It was below those levels in 23% of white hypertensive and 25.2% of black hypertensive patients respectively. The mean level of plasma renin activity fell with increasing age of hypertensive patients. This procedure is recommended as a safe, easy, and reliable test for assessing renin responsiveness and identifying the low renin state.

Original languageEnglish (US)
Pages (from-to)639-645
Number of pages7
JournalUnknown Journal
Issue number6
StatePublished - 1976
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine


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